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Does CBD Affect Heart Rate?

Updated January 15, 2024

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The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.

Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

Cardiovascular diseases remain the leading cause of mortality. But, more importantly, it remains the primary cause of disability and mounting costs in healthcare.

Most cardiovascular conditions are chronic, like hypertension, atherosclerosis, coronary heart disease, and heart failure.

In heart conditions, a high heart rate is not good, as it makes the heart work faster and increases its needs for oxygen and other nutrients, thus increasing the risk of a heart attack. On the other hand, keeping heart rate lower is preferred, as it helps control blood pressure and lowers stress on cardiac muscles.

For a long time, researchers knew little about the influence of cannabinoids on heart health. Since CBD was illegal just a few decades back, it was impossible to carry out clinical trials or even lab studies. However, now things have changed, and using CBD in clinical trials is legal and ethical.

Effects of CBD on your Heart Rate

The most beneficial effects of CBD seem to occur due to its impact on the endocannabinoid system (ECS). At first, researchers thought that ECS is mainly present in the brain. However, now they understand that it is present in almost every organ. Thus, it is present in blood cells, adipose tissues, heart muscles, blood vessels. It can influence inflammatory responses, blood pressure, heart rate, platelet aggregation, and much more.

It seems that now researchers understand how cannabis can affect heart rate. Judging by this research it appears that ECS activates or deactivates the transient receptor potential cation channel subfamily V, member 1 (TRPV1). Studies point to TRPV1 being activated by THC (tetrahydrocannabinol). And on the contrary, the cannabinoid is a strong desensitizer of TRPV1.

Additionally, the latest studies also show that CBD may have a much broader impact on heart health. It may alter inflammatory responses, help prevent the formation of plaques, may exert a protective action on the cardiovascular system.

CARDIA (Coronary Artery Risk Development in Young Adults) cohort study confirmed that not only CBD but even recreational marijuana appears to be safe for heart health. However, unlike CBD, marijuana is more complex, as it contains various compounds with opposing effects on ECS receptors. Therefore, understanding a single compound and its impact on heart health is more straightforward.

What does CBD do to your heart rate

Since CBD is a desensitizer of TRPV1 channels, it has a mild calming effect on the heart. In addition, it tends to slow down the heart rate, which is beneficial for those living with hypertension or those at the risk of a heart attack. It also lowers the metabolic rate in heart muscles. However, it is worth noticing that CBD only has a mild effect on the heart.

Generally, the THC heart rate effect may be stimulating, and the CBD heart rate effect would be calming.

At present, there are not many studies regarding its impact on heart rate. Nonetheless, most observations indicate that it may help keep the heart calm. It is vital to understand that it mildly lowers the heart rate and, more importantly, may slow down unnecessary cardiac response to minor stressors. It means that it reduces the heart rate variability, which may be pretty good for the heart.

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Heart rate variability and CBD

There is a difference between the heart rate at rest and the heart rate under stress (physical or emotional). Greater variability in the heart rate is bad for heart health.

However, it is essential to know that individual sensitivities differ, and in some, CBD may instead cause a mild increase in heart rate along with lowering blood pressure. This increase in heart rate is more common after the first few dosages (acute ingestion) and only when CBD is used at extremely high doses like 600 mg a day. However, in most people, a moderate dose of 70 mg a day would only have a calming effect. Nonetheless, it is vital to remember that its heart action will depend on the dosage and will change over time.

Additionally, it is also worth noticing that CBD has many indirect benefits for heart health. It may lower fast heart rate due to its ability to counter anxiety and other emotional responses.

This means that CBD may be suitable for controlling heart arrhythmia. It can lower heart rate, and it may even help prevent irregular heartbeats. Thus, one can also use CBD for heart palpitations, which are commonly caused by either fast heart rate or irregular beating of the heart. Although its effect would be mild, but beneficial. In fact, its mild effect is a good thing, as it means that people can use it frequently without worrying about the side effects or the need for consulting a doctor.

Taking CBD when you have Heart Issues

There could be many reasons to take CBD when living with a heart condition:

Hypertension: CBD generally lowers blood pressure. Its blood pressure-lowering action appears to be mild at the recommended dosage of below 70 mg/day.
Heart rate control: its effect will vary. At the recommended dosage of 70 mg/day or below, it will have a calming effect. However, a very high dosage of 600 mg may cause an increase in heart rate. Further, the body will get used to it with time, and it will have a minimally calming effect. Additionally, CBD will also reduce heart rate variability.
Myocardial infarction: usually, it would help reduce inflammation, improve blood flow, and thus boost cardiac function. It may reduce episodes of cardiac pain.
Atherosclerosis: ECS system is also widely present in macrophages and vascular smooth muscles. Its dysregulation increases the risk of plaque formation. CBD may help regulate ECS and thus lower the risk of atherosclerosis.

ECS regulation with the help of CBD appears to be one of the promising approaches for managing heart issues. CBD oil is good for lowering heart rate, overcoming palpitations. It also helps prevent or manage more severe conditions like arrhythmia, ischemic heart disease. However, these are still early days, and there is a need for more studies in humans.

Recommended CBD Dosage

Since individual sensitives vary, so does the dosage. 10 to 20 mg a day would be a good starting point for those taking CBD for the first time. Generally, a dosage of 70 mg a day is regarded as moderate and highly safe. However, one should be a little careful if exceeding this dose. Nevertheless, it is worth noticing that CBD is safe even at much higher dosages like 600 mg or even 1000 mg a day. But, at higher dosages risk of adverse effects is also higher.

Safe and legal, CBD has the potential to change the shape of people’s health for the better. Get in contact with us and find the various CBD options we offer!

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Is CBD Oil Suitable for Pet Rats

Updated January 15, 2024

Written by

Simon Šfiligoj

CBD Manufacturing

Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

Though keeping rodents as pets may not be for all, but they can be a good friend. Rats are highly social animals. They might be considerably smaller than dogs or cats, but they are highly intelligent and have an excellent memory. Though their vision is not very sharp, once they have learned to navigate places, they never forget the path.

A more important reason for keeping rats as pets is that they are indeed social animals. They like to live in families. It means that they can accept their human companion and show affection. For example, they may enjoy a massage and may even react to tickling.

For humans, keeping rats as pets can also be quite rewarding. They recognize various emotions. They would do various things to attract the attention of their human friends. Thus, rats can also be good companions for humans.

Would CBD oil work for rats?

Mammals come in various sizes and forms. Even dolphins and whales are mammals, but they have quite a different metabolism compared to rats and cats. So, what may work well for one species may not necessarily work well for another.

Nonetheless, it is worth noticing that many hormones, receptors, hormone pathways are well preserved within all mammals. So, despite the differences, mammals do share a lot. That is why insulin extracted from swine works in humans. It does not mean that swine insulin is precisely the same. It differs. Swine insulin has different chemical structures, but amazingly most parts of the molecule responsible for its function are well preserved in various species. It means that even insulin from a fish would influence humans.

It means that generally, most drugs have a similar action in various mammals, but with some differences. For example, some mammals may be more sensitive to alcohol, marijuana, or CBD, and others less. Nonetheless, the effect is generally predictable. It also means that what works for humans would mostly work for other mammals, including rats.

Another proof of the concept could be veterinary medications. Most medical drugs used in humans work in other mammals, too.

However, there are some challenges in using substances in mammals. There is a massive variation in metabolic rate, and even more importantly, in body sizes. In animals, this variation may be huge, even within a single species. It means that rats would generally require a very low dose of CBD.

Rats are pretty similar to humans

Ever wondered why rats are so commonly used in lab experiments? Why are drugs often tested in rats and mice before they are given to humans?

The explanation is simple. These small and humble beings share many traits with humans. Modern studies show that their genome contains an almost similar number of genes as humans. Thus, humans have 2.9 gigabases (Gb) of genes, and rats have slightly less at 2.74 Gb. But, that’s not all. Studies show that at least one-fourth of all genes between rats and humans are exactly the same.

So, the answer to can rats have CBD is yes.

Rats have similar kind of health issues as their humans

These days, for humans, the greater concern is non-infectious diseases or metabolic disorders. These disorders are the result of an altered lifestyle. Human diet has changed considerably in the last century or so and the level of physical activity.

Pet rats also have challenges similar to their human companions. They are physically less active than non-pet rats. In addition, they have a very different dietary pattern. It means that pet rats are also prone to metabolic disorders, obesity, bone disorders, hypertension, pains, and even oncological conditions.

Pet rats are fed differently. In addition, they have limited space to move around. As a result, pet rats have a very different lifestyle compared to rodents dwelling in the wilderness.

Why use CBD oil for pet rats?

One of the issues is that veterinary medicine is not ready to take care of pet rats adequately. It is mostly focused on preventing lice, fleas, worms, and some infections in rats. However, there is almost no focus on non-infectious diseases. Neither much effort is made to improve the quality of life, prevent metabolic disorders, help with pain, improve anxiety, help with sleep issues.

It means that many pet owners have to tackle these issues of their small companions by themselves. And it is where CBD may help. Moreover, CBD oil for pets may help prevent various disease conditions.

Some of the ways in which CBD oil may help pet rats

Pet rats are prone to metabolic disorders, eating disorders, and much more. This is because their diet when living with humans is quite different. Moreover, their human counterparts cannot understand all the intricacies of rodent diet.

Studies show that CBD oil may help prevent obesity and related disorders in rats. It may help by influencing dietary habits and boosting metabolism.

Similarly, CBD may also help overcome pains, boost memory and learning in rats. It may help slow down age-related disorders. Thus, supplementing the diet of a pet with CBD may help keep it active.

CBD may also help reduce pain, have a calming effect. Studies show that it may reduce nausea, exert an anti-emetic influence. And thus, it may improve appetite in ill pets.

However, here is a word of caution. One should use much lower dosages of CBD in pet rats than in experimental studies. It is essential to remember that experimental studies are not done by keeping rats’ well-being in mind. They are simply done to demonstrate certain concepts so that similar ideas can be later applied to humans. Thus, most experimental studies may give toxic doses for quick results.

Thus, for example, CBD dose for rats with tumors would be just a few milligrams. Perhaps 1 to 3 milligrams would work for most, considering that 70 mg is considered a moderate dosage for humans.

Another essential thing to remember is that it would be better to avoid THC in the rats. It is not because it is toxic for rats, but its effects may be challenging to predict. Instead, it would be a good idea to use CBD isolate. Even broad-spectrum CBD may have unpredictable results.

To conclude, rats can be excellent companion animals. However, there are specific challenges in taking their care. CBD may help prevent various disorders in rats. It may have a unique role in preventing some diseases in rats, especially considering that veterinary doctors are not much aware of non-infectious conditions in pet rats.

Have you ever thought of adding CBD to your pet’s diet? Reach out to us and find out which option we offer as white label CBD for pets.

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Expert Tips on How to Scale a CBD Business

Updated January 15, 2024

Written by

Simon Šfiligoj

CBD Manufacturing

Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

Starting a business is possible even at a shoestring budget. However, lower initial investment also leads to lower turnovers and profits. Most individuals would feel a need to scale once they have mastered the basics. Nevertheless, many people struggle with the issue, as they might have a successful business, but not at a scale they would like.

However, one should not be discouraged and remember that even companies like Google and Amazon started their journey from a garage.

Scaling your CBD Business for Success in the CBD Market

First, one needs to understand that growth and scaling are two very different terms in business language. Growth is when a person increases business revenues through a proportionate amount of investment—in contrast, scaling means looking for ways to expand the business without a considerable increase in investment.

Growth is not that bad as it helps get a more significant share of the market, boost brand value. However, as one can guess, scaling is the key to long-term success in any business.

Classical strategy to scaling is increasing the depth and width of business. It primarily involves expanding to new geographies or markets (e.g., within the country or internationally), expanding the product portfolio with a particular focus on brand extension as it helps save costs, and considering new ways of communicating with clients (expanding promotional strategy).

However, experts at Harvard business school recommend avoiding certain pitfalls like scaling too fast and too early, focusing on quantity and not quality, losing business focus, making all decisions, and being unable to delegate tasks.

Keeping Updated on the Changing CBD Laws & Regulations

One of the challenges for those looking to expand the business is the different CBD laws in various geographical locations, and more importantly, continually changing regulations.

The CBD market is a fast-growing market. However, it also means that it is not a mature market and lots of changes keep happening at a fast pace. Just take an example of the classification of CBD as novel food by the EU. For those not ready for this law, it created considerable problems.

Additionally, when it comes to promoting products, laws also differ. For example, promoting CBD for pets in the UK may get any company into trouble. Moreover, laws regarding health claims are very different in the EU from the UK and the US.

Even within the EU, laws may differ. It is vital to understand that some countries may ban certain CBD products on health concerns, even if those products were legally produced in the EU.

Just take the example of vaping. There is a growing concern regarding health risks associated with it—the EU commission is considering bringing CBD vapes under the tobacco regulation act.

Choosing the Right Supply Partners

When looking to scale a business, one needs to find a supply partner with expertise in various CBD business areas, from providing private labeling, CBD wholesale, dropshipping, etc.

Since, in the long term, the focus should be on quality, and only quantity will follow, one should look for a wholesale supplier with excellent expertise in producing various CBD products from isolate to distillate. For example, it could be a good idea to consider water-soluble CBD isolate and distillate. In addition, CBD wholesale companies should also be able to provide equipment for in-house production and provide tech know-how.

CBD eCommerce: Selling CBD Online

For those new to eCommerce, there could be numerous ways of selling their products online. Nonetheless, all the online selling ways can be divided into two groups:

Selling through eCommerce platforms. It is the most straightforward way of selling CBD products. Platforms like Amazon are global. But then every European nation has other local major players like Otto and Zalando in Germany. The good thing about these platforms is that they are like a huge mall, and clients regularly come to them. On the downside, they may not allow sales of CBD in some countries, and there may be hassles of account approval. Further, they may take a considerable commission from sales.

Dedicated CBD sales platform: It means creating a dedicated online store, like with the help of Shopify, WooCommerce, and so on. Here options are unlimited. These stores have certain upfront costs, but it is not very expensive to create an online store. The most significant benefit is that such stores are the property of the owner. Thus no one can ban them, ask for commissions. On the downside, it is like creating a shop in an isolated place, and no one knows about it. Thus, a need for substantial promotional investments. Like promoting a product via social media, google, Insta, Facebook, and so on. Promoting the store on some local channels in the country may be an economical option.

Product sourcing is another issue. There are multiple ways of product sourcing both for beginners and experienced players. It could be CBD dropshipping business with practically no need to hold stock, but it also means a lack of sufficient control over the supply chain. Or buying CBD wholesale from private labelers, and finally, setting your own production.

Advice on Expanding your CBD Product Portfolio

The CBD market is growing at a fast pace, with a CAGR of almost 30%. That is way higher than most industries. However, competition in CBD is also increasing fast. Nonetheless, CBD business opportunities are many.

Differentiation is the key to long-term success.

It is the basics of marketing. One should be able to differentiate the product from others. If it is just another CBD oil, that may be challenging to sell. Further, consumers must be able to understand that difference. There are many strategies for creating products that stand out.

Firstly, focus on value-added products. Days of simple CBD oil are long gone. Thus, develop a product with added health benefits. This doesn’t mean increasing the concentration of CBD. But creating a unique product by adding terpenes, essential oils, and other cannabinoids to CBD oil. Doing so may help to make a product that is especially good for specific health conditions like calming nerves, promoting sleep, improving skin health, anti-aging, preventing headaches, and much more.

Another good way to scale things could be focusing on a special user group. Thus, one may come up with CBD products specifically for sportspeople or active lifestyle, women health, topicals, cosmetics, veterinary products, to name a few. It would be a good idea to provide a range of products that focus on one of these segments, rather than trying to expand with single or some sub-quality products in all these segments.

Tips for financing the business

Doubts that banks or other financial institutions may not finance the CBD business are unfounded. Banks finance legal business activities or legal entities in any given nation. Thus, a legal entity may apply for a business loan based on the business plan and apply for a loan for equipment purchase or equipment lease.

Of course, there are also microlenders, and they are generally more flexible. However, the interest rate of such lenders tends to be higher.

Indeed, there are other flexible ways of finding investment, like offering the stake in your business to various lenders. These could be friends, venture investors, angel investors, and much more. The only thing to remember is that most investors, be it institutional or angel investors, will ultimately look at a business plan that is realistic, doable, and flawless.

The first step is always the hardest one. But don’t worry, Essentia Pura will help you kickstart your CBD business! Get in touch to find out more about programs we offer for upcoming businesses. Already an established CBD business and ready to grow with us? Just compile the web form on this page!

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Analysis of the CBD Cosmetic Market

Updated January 15, 2024

Written by

Mag. Valentin Mis, LL.M.

CBD Legal

Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

The CBD cosmetics market has been growing continuously for a decade and the year 2022 was no different. This trend of rising popularity is largely a product of the growing awareness about the advantages of CBD in skincare and beauty products. This means that the public is more prone to accepting these kinds of products, especially when it comes to skin conditions such as dry skin, eczema, psoriasis and even acne.

Times were never so exciting for investing in the CBD cosmetic market. The year 2021 has been revolutionary in many ways. It demonstrated how mature and resilient the industry is as it kept growing even in pandemics. But more vitally, it has been a year of improved European regulations.

The European Union has finally recognized cannabidiol (CBD) as safe for adding to cosmetics. Until now, only synthetic CBD could be added to cosmetics. But in February 2021, the EU added cannabis extract or resin or tincture to the CosIng database, which is the European database of components that may be added to cosmetics. This means that it is recognised as safe for adding to cosmetics, and thus increasing the requirement for organic CBD oil. This decision has definitely provided a much-needed impetus to the CBD cosmetic industry. As lack of clarity in specific regulations, the risk of being fined kept European manufacturers from venturing into the CBD cosmetic market.

In fact, European Industrial Hemp Association (EIHA) proposes a three-tier approach in its position paper:

To strictly regulate high dose CBD products and consider them as medications.
Recognize a medium dose of up to 70 mg/d as food supplements, thus allowing its wider use, like silymarin, ginkgo biloba, or certain vitamins.
Allow wider use of low concentration CBD in food products, cosmetics, and other items for daily use.

But the progress did not stop here. Although there have not been any major changes in the past year, the debate about CBD in cosmetics is as alive as ever and has made the European market of CBD infused cosmetics and self care products a fast growing industry. The most obvious obstacle that is holding back this region is that every country has its own specific laws. This makes it more difficult for manufacturers who have to tweak their products to satisfy each country’s preferences.

CBD Cosmetic Market Size

The CBD infused cosmetic market remains quite disintegrated, and numerous players dominate it, some of them being: Infineon Technologies AG, The CBD Skincare Co, Endoca BV, Cronos Group Inc, Joy Organics, Elixinol Limited and many more.However, such a scenario offers lots of opportunities for new entrants since entering the consolidated market dominated by just a few brands would be more challenging.

There is poor understanding regarding the exact size of the global CBD cosmetic market, as data is quite hazy. But The analyst has been monitoring the CBD-infused cosmetics market and it is poised to grow by $ 3.15 bn during 2022-2026. And what is more attractive is that this segment continues to be fast growing.

CBD has provided many small-time players to come up with value-added, premium cosmetics. However, the good thing about CBD infused cosmetics is that many lesser-known players are able to charge a much higher price for their products.

CBD is now in almost every kind of cosmetic product ranging from beauty products like mascara to skincare creams, moisturizers, facemasks, oils, cleansers. It is also more prominent in products for acne treatments.Some companies are also introducing CBD infused products for more specific needs like helping with oily skin, managing acne, reducing skin irritation, and much more.

CBD Cosmetic Industry Growth

Here again, the projections differ. Nonetheless, the market report by Technavio suggests that the market has witnessed a CAGR of nearly 25% in the last few years, and this growth rate is only expected to accelerate.

*Figure 1:* Technavio report on CBD cosmetics and expected growth

Despite the steady growth of the European market, there is no doubt that the US continues to dominate the market. It is because the EU has been more stringent regarding the widespread use of CBD. Furthermore, European agencies took longer to legalize CBD infused cosmetics.

In addition to being the biggest market region, the US will also continue to see the biggest growth: over 40 % of global market growth is expected to originate from this region. However, the EU is picking up the pace and may even become as strong as the US market in the near future, or even exceed it.

Entering this segment may help existing CBD manufacturers to expand their portfolio. In addition, the existing cosmetic producers are starting to come up with their own CBD infused cosmetic products,which is strengthening the market even more. It is evident that CBD infused cosmetics will continue to enjoy premium prices in the foreseeable future.

Current CBD Cosmetic Industry Trends

Most trends clearly indicate that CBD is bound to become one of the essential components in the cosmetics industry. The ongoing research will ensure its growth and supply new, innovative products to keep the market interesting.

Many chose products with CBD because of its benefits for skin like antioxidants, skin conditioning, skin protection, and even anti-sebum. It can considerably help overcome skin redness, dullness and has a calming effect.

This is why customers are not just looking for a beauty product but also to get rid of some minor skin- related issues. To accommodate this demand, vendors are focusing on making specific products that implement new strategies to help with hair and skin related issues. Many focus on creating premium ranges to try and enter the luxury market. This is an effective strategy to secure your place in the industry. And as luxury products become more popular, the demand for more affordable options also rises, creating a steady increase in popularity. The luxury market is also a great place for introducing organic cosmetics including ingredients such as aloe vera, sea salt, shea butter, mango seed butter, lanolin, and others, which are preferred by consumers at present.

CBD oil is still quite a new trend in cosmetics, as evident from the graph below. Although there has been some interest in it for the last 10 years, it has really picked up from 2017 onwards. The growth of interest in CBD oil is incredible.

U.S. CBD skin care market size, by type, 2015-2025 (USD Million)

Is CBD going to be the next big thing in cosmetics? The trends of the beauty industry seem to confirm that. We may start seeing some more CBD oil makeup products start popping up in the near future.

*Figure 2:* Sudden increase in “CBD skincare” search since 2019 (source: Google trends)

Essentia Pura’s Analysis of the CBD Cosmetic Market

Here are Essentia Pura’s takes on the CBD cosmetic market:

It is still a nascent market, with low market access costs
There has been a sudden increase in interest in CBD cosmetics since 2019, thus a sudden upsurge expected in the market in coming years
CBD market in EU may pose CAGR of above 30% for next five years, or at least up to 2025
The legalization of natural CBD extract and its addition to the CosIng database will further boost the EU CBD cosmetics market
One can still expect a premium price for CBD cosmetics
Demand for CBD cosmetics private label will increase

The market’s strongest area continues to be skincare, boasting the largest range of different products. Medical news today lists the best CBD products to be lip balms, serums and face and body creams. Many of these items have the common characteristic of being hydrating. Another great source if you want to try some new CBD infused cosmetics is allure, who created a list of products with the help of their readers.

Opportunities for CBD Cosmetic Businesses in 2022

CBD can be added to almost every kind of cosmetic product. Therefore, it does not essentially have to be targeted at managing some skin conditions. In fact, decorative cosmetics will remain a bigger segment than cosmeceuticals. Thus, more people would buy CBD infused mascara or day-to-day skincare products than CBD products for managing acne.

People buy CBD cosmetics due to perceived benefits. They believe that CBD cosmetics are in some way superior, and it may be the case in some instances. Thus, CBD infused creams, moisturizers, serums, soaps, masks, lip balms, and eye balms are all in trend and offer opportunities.

To conclude, CBD cosmetics offer an excellent opportunity to expand the existing CBD business. It is an equally good segment for newcomers. It is still a segment in its infancy, ready to witness a boom in the coming years. Take your step into the CBD cosmetic market with our white label CBD skincare line. Fill the contact form for your order or send us an e-mail with any questions or concerns about our products.

Take your step into the CBD cosmetic market with our white label CBD skincare line. Fill the contact form for your order or send us an e-mail with any questions or concerns about our products.

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What we know about Delta 8 THC

Updated January 15, 2024

Written by

Mag. Valentin Mis, LL.M.

CBD Legal

Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

We know that cannabidiol (CBD) is just one of the cannabinoids in the hemp or cannabis plant. Most cannabinoids are chemically related. These chemically related substances share traits, health benefits. Nonetheless, they are different, and each of the compounds has unique effects on health.

In fact, it is not rare for the industry to look for chemically related compounds. Chemically related compounds may have similar actions, but each may have unique benefits. Just take the example of antibiotics called beta-lactams. It all started with the discovery of penicillin, but now we have numerous antibiotics in the group that are better than penicillin, like ampicillin, amoxicillin, and so on.

Since delta 9 THC (regular THC) is a banned substance, there is an increased interest in substances related to it. Delta 9 THC causes euphoria, and it is addictive. Still, at the same time, it may be pretty good for specific disease conditions like countering anxiety and panic. So, can delta 8 THC be regarded as its safer and legal analog?

What is Delta 8?

Delta 8 has suddenly gained lots of popularity in certain groups. This is because people are actively looking for something that could be as good as regular THC, but with a much better safety profile.

Delta 8 is quite similar to delta 9 in its chemical structure, with only a small difference. However, the molecule is a little smaller and has much lower potency when compared to its bigger brother delta 9 THC. Nonetheless, it must be understood that both are forms of THC. Nevertheless, when people are saying THC, they generally refer to delta 9 and not delta 8.

Vaping is the most common method of delta-8-Tetrahydrocannabinol consumption

What is Delta 8 Legal?

It is one of the complex questions. However, since most of the delta 8 is extracted in a similar way to delta 9, they appear to have a similar legal fate.

Nevertheless, how substances are regulated differs a lot. For example, even in the recreational drug industry, it is not rare to develop some potent psychotic agent, which is not illegal in the books. It means that if someone creates an entirely new chemical with a mild-altering effect, it may remain legal for some time before regulatory agencies step in.

And the same is valid for delta 8, which falls into the gray area. It is not entirely legal, as it retains the main properties of a typical psychotic agent. Nonetheless, due to the lack of enough data, it may remain legal in some places.

Most nations or states are just starting to classify delta 8, which is already legal in some states of the US. While in parts of the EU, it may be legal or illegal.

Nonetheless, its minute amounts in CBD would be legal. Quite like regular THC, if delta 8 is in amounts that do not cause euphoria (less than 0.2%), it remains legal.

Does Delta 8 make you High?

Many people are looking for ways to experience a legal high. It is this category of individuals highly interested in delta 8. Additionally, some people are always looking for something not as potent as delta 9 THC and can yet provide some high or similar relaxing effects at lower dosages.

When comparing delta 8 vs delta 9, it appears that delta 8 is very similar to delta 9 in most of the ways. Unfortunately, due to ethical reasons, there are not many studies. Nonetheless, it is worth knowing that delta 8 was discovered way back in the mid-20th century. Some of the early studies suggest that oral or intravenous delta 8 is quite comparable to delta 9.

But again, the experience of marijuana enthusiasts varies greatly from clinical researchers. Clinical researchers have a narrower approach, and they are only interested in whether delta 8 causes high or not. They are not interested in exploring the quality of the high. On the other hand, people who have used delta 8 describe it as much lighter, having greater relaxing and energizing properties.

So, does delta 8 get you high? Yes, both the researchers and cannabis enthusiasts agree that delta 8 can give high.

How is Delta 8 Extracted?

Delta 8 is in very small amounts in the legally grown hemp plant. Thus, the most common way of its production is through the conversion of pure CBD to delta 8 THC.

Most CBD manufacturers would start with decarboxylation, also called decarbing of the plant material. It involves heating hemp material to a certain temperature, which converts CBDa to CBD and thus helps improve the quality of raw material.

The next process would be CBD extraction. For this, most would use one of the methods that are oil extraction, solvent-based extraction, and solventless extraction (supercritical CO2 extraction).

After this, the next logical step is creating high concentration CBD with the help of winterization and distillation. It produces 99% pure CBD isolate.

Needless to say, that manufacturers can skip the steps above and can start with CBD isolate, which is commonly available.

Next comes the most critical step called rapid isomerization of CBD, which can help convert CBD to either delta 9 THC or delta 8 THC.

clear delta-8-Tetrahydrocannabinol distillate should be an indication of quality.

For CBD isomerization, producers would generally dissolve CBD into glacial acetic acid. This will initially convert CBD to delta 9 THC; however, THC created this way is not stable, and it will ultimately convert to delta 8 after about 72 hours.

It is worth knowing that researchers also know other ways of synthesizing delta 8 THC by using other organic compounds as a base.

Where is Delta 8 Available?

Delta 8 is still widely available on various online platforms, with varying degrees of purity. It is available in powder forms and as a delta 8 flower. It still remains legal in most parts of the EU and many parts of the US.

However, its future is unclear. If recreational use of marijuana becomes legal in the future, then the future of delta 8 also seems bright. Nonetheless, there are chances that various drug enforcement agencies may go against delta 8, and there are high chances of it becoming illegal.

To conclude, delta 9 THC causes euphoria and is addictive. Nonetheless, it has an excellent relaxing effect on the brain that is not possible with CBD alone. So, it means that people are looking for something that may have a mind-altering impact closer to delta 9, and still, it should be legal. At present, delta 8 is one such option and a legal option in parts of the world.

Essentia Pura is focused on full spectrum extracts of industrial cannabis, but the uprising of compounds such as delta-8 THC, which are rare in hemp are intriguing. Which minor cannabinoids do you believe will be the next big thing? Let us know!

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Do CBD patches work?

Updated January 15, 2024

Written by

Simon Šfiligoj

CBD Manufacturing

Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

Everything you need to know about CBD patches

There are numerous methods of drug delivery, and the same is true for CBD products. Each delivery method has its pros and cons. A transdermal patch is a way of creating extended-release CBD products. Transdermal patch releases active ingredient slowly for hours, in some cases even in days.

In recent years, there has been increased interest in CBD patches, Hemp patches, Cannabis patches.

What are CBD patches?

Transdermal cannabinoid patches are non-invasive. It is a patch with adhesive applied to a specific part of the body. Once applied, CBD is slowly absorbed via the skin.

Many people find a CBD oil patch more comfortable than oral CBD oil. As, in this case, there is no need for multiple dosing during the day. One may simply apply the patch and forget about it.

Patches are slow to work but have a prolonged duration of action. They also help gain more predictable levels of the active ingredient in the blood as the patch slowly keeps releasing it. It means once an adequate amount of CBD has reached the blood, it will remain in that steady-state for hours. Thus, in specific chronic conditions, patches may be more effective.

Like other methods of delivery, not all patches are created equal. Some are made for a faster and short duration of action. Others are designed for prolonged activity. Some may use absorption enhancers to increase the efficacy of the product.

How do CBD patches work?

Transdermal drug delivery is one of the oldest methods. Ancient practitioners have also utilized this method. Ancient people would often apply various herbal oils and pastes and cover them with leaves or cloth. However, modern medicine has been slow to pick up this route of drug delivery.

It has a very simple mechanism of action. When CBD patches are applied, CBD gets absorbed via the skin and enters the systemic circulation.

This route provides some distinct benefits like a steady-state of CBD in plasma, no first-pass metabolism, or degradation of CBD. No loss of CBD in the intestinal tract. Prolonged duration of action and improved patient compliance.

However, there are some variations in CBD absorption depending on age, ethnicity, skin hydration, gender, and so on. It means that manufacturers should test their products in various population groups before their commercial introduction.

There are already some early bioavailability studies showing that this route of administration works for CBD. Studies show that transdermal patches are slow to start acting. It may take few hours before any considerable amount of CBD could be detected in the blood.

Bioavailability study shows that transdermal patch achieves steady plasma concentration after several hours. However, once this constant state is achieved, it is easier to maintain it than other dose forms. It means that patches are especially good for chronic painful conditions. Further, the bioavailability study shows that steady-state CBD concentration can be increased several folds by adding a permeability enhancer.

Transdermal CBD is preferred in many health conditions. CBD patches for pain relief are popular. CBD patches for anxiety are another area of interest.

Where do I put my CBD transdermal patch?

It is vital to understand that skin patches only work if applied correctly. For example, skin patches should not be applied to irritated or injured skin. In addition, one should not put a patch into the mouth or chew it.

When applying a patch, one should use certain precautions like not touching the adhesive side of the patch. Doing so may have an impact on how the patch works.

So, where do you place a transdermal patch?

Before starting, one should ensure that the skin is clean and dry. It could be especially important for those living in warmer climatic zones with lots of sweating. The best place to apply a patch is on the upper arm, chest, or even back. One should preferably apply a patch at places that do not move much.

Another essential thing to remember is that not to apply a patch on hair parts of the skin. It is because the patch would not stay in its place for long. Further, the presence of hair would also alter the rate of absorption.

If one needs to clean a part of the skin before applying a patch, it is better to use plain water. Likewise, one should avoid using oils or even alcohol-based cleansers.

After applying the patch, press it firmly for about 30 seconds to ensure it stays in place.

How long any patch can be applied would differ, as the technologies used to produce patches vary significantly. For example, some patches are made to be applied once every day. However, certain technologies might allow 72 hours of action.

Manufacturing CBD patches

The manufacturing approach would differ, as there are numerous proprietary technologies available. Each technology has its pros and cons. Some may provide better adhesive properties, while others may have higher bioavailability and prolonged duration of action. Therefore, a CBD transdermal patch manufacturer would need to explore some technologies.

Most patches would have these five components:

Protective liner: It is removed before the application of a patch. Its role is to protect the patch when it is stored. It may also help enhance the stability and shelf-life of the product.
Drug reservoir: It is precisely where the active ingredient, that is, CBD, is contained. There could be certain technologies to ensure that a definite amount of CBD can be applied to any patch.
Drug release membrane: It is generally regarded as the most vital component of any transdermal drug delivery patch. This membrane comes directly in contact with the skin, and the rate of drug release or CBD release is highly dependent on this membrane. Therefore, this membrane must be compatible with CBD.
Contact adhesive: It ensures that the patch sticks to the skin. Again, there are numerous medical-grade adhesives available with various degrees of sticking strength. Strong adhesive is not necessarily better as the patch must be removed, too. The adhesive ought to be hypoallergic to avoid local skin reactions.
Clear backing: It protects a patch from outside contamination.

To conclude, transdermal drug delivery is not new, and neither is its use in medicine. Transdermal patches were first approved by US FDA and European nations in the late 1970s. It means that there is a lot of experience in using patches for drug delivery. There are numerous drugs available in this form. CBD patch manufacturers need to build upon this extensive experience of the pharma industry with patches.

What is your opinion on the CBD transdermal patches? Share your thoughts with us at info@essentiapura.com

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5 minute read

Can you add CBD Oil to Essential Oils?

Updated January 15, 2024

Written by

Simon Šfiligoj

CBD Manufacturing

Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

CBD and Essential Oils

Essential oils are derived from various parts of the plants, and they usually retain the odor of that particular plant. They are pretty volatile. They might be extracted from leaves, peels, flowers, bark, seeds, and so on.

There are thousands of known varieties of aromatic plants. It means that there are thousands of types of well-documented essential oils. These plants are also commonly referred to as medicinal plants due to the innumerable health benefits of these essential oils.

Researchers are still trying to decode the secrets of essential oils. They are made up of hundreds of complex organic molecules like terpenes, phenol-derived aromatic compounds, and much more. These compounds also have multiple health benefits like antioxidant, anti-inflammatory, antimicrobial, immunomodulatory.

More interestingly, they have a wonderful aroma that may cause various psychological responses like relaxing, stimulating, mood-elevating, and much more.

Since these molecules are so complex, researchers still have a very limited understanding of essential oils in any given plant. Nonetheless, science has identified thousands of aromatic molecules in essential oils like beta-pinene in basil or alpha-limonene in lemon.

For those interested in learning more about essential oils (as there are so many essential oils) and various aromatic and non-aromatic compounds in them, there are few excellent freely accessible databases like AromaDB or EssOilDB. One may use these databases to learn more about different essential oils and creating unique products.

Is CBD an Essential Oil

Users often ask, is CBD considered an essential oil? CBD is just one of the chemical compounds found in the cannabis plant. It is a short form for a compound called cannabidiol (CBD). Since essential oils are a mix of numerous aromatic and volatile compounds, CBD isolate cannot be regarded as an essential oil. It is just one of the compounds found in cannabis oil.

It is also vital to understand that CBD oil and Cannabis oil are different terms. CBD oil may be created by adding CBD isolate or broad-spectrum CBD distillate to any carrier oil (olive oil, coconut oil, and so on). Cannabis oil, on the other hand, is a raw product, an essential oil extracted from the cannabis plant.

Nonetheless, broad-spectrum CBD distillate is quite close to essential oils, as it contains other organic compounds, cannabinoids, terpenes, and so on.

The reason why the industry does not use cannabis oil and instead utilizes CBD isolate or distillate to make products is that cannabis oil has very low CBD content.

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However, researchers understand that the benefits of CBD products can be considerably enhanced by combining CBD with various other essential oils. Or another approach is to add different terpenes to CBD products to create designer, value-added products.

Combining CBD with specific essential oils or terpenes results in products with known particular properties. Researchers believe that in the future, this would help create CBD products for specific health conditions.

Adding CBD to Essential oil

There are many reasons to add CBD to essential oil. One of the simple reasons could be that there is a need for a carrier oil. Further, CBD oil and essential oils may help boost the health benefits of each other (via entourage effect).

Some benefits of adding CBD to essential oil

Here possibilities are innumerable, and one may add CBD to lavender or chamomile essential oil for creating stress relieving product. It may help relax better, induce sleep, and have an enhanced calming effect.

If one wants to create something with a mood-elevating and energizing effect, adding CBD to lemon essential oil would be good.

Similarly, adding CBD to eucalyptus essential oil may help create a product with good anti-inflammatory and antimicrobial properties.

Some people love the cooling effect of peppermint oil. In addition, CBD-infused Peppermint oil may also be suitable for pain relief.

Jasmine has a mild mood-elevating effect. It may help counter stress, help with depressive mood, and much more.

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Adding terpenes to CBD oil

It is another new approach to creating products with remarkable health benefits. Some manufacturers are now adding terpenes to CBD oil. Here too, the possibilities are innumerable, and hundreds of terpenes are commercially available with distinct health benefits.

Limonene– as the name suggests, is extracted from citrus fruits and can add to CBD oil a citrusy aroma. It is especially good for reducing inflammation and helps combat stress. Researchers are also exploring its other health benefit like antimicrobial properties.
Alpha–Pinene– is derived from pine needles, basil, rosemary, and other plants. Pinene can provide good anti-anxiety properties. It is also suitable for respiratory health and has mild bronchodilatory action. Meaning it’s better for those living with various chronic conditions of the respiratory tract.
Myrcene– a terpene with a musky smell, has antibacterial and antioxidant properties. It has a sedating effect on the mood and thus may be suitable for improving sleep quality.

Here the possibilities are countless like beta-caryophyllene (spicy aroma) is good for neuroprotection, linalool (floral scent) relieves anxiety.

Some people like to use CBD essential oil diffusers for aromatherapy, too. So, one of the questions asked is, can I put CBD oil in my oil diffuser? Well, the answer is that it is possible in some cases, but not all cases. If CBD is added to essential oil, then it is suitable for use with a diffuser. However, many CBD oils do not contain essential oils and are made explicitly for ingestion.

CBD Essential Oil benefits

Essential oils are not just carrier oils; they also provide the so-called “entourage effect,” thus considerably enhancing the health benefits of CBD.

Cannabis essential oil is generally regarded as moderately antibacterial. It is good for anxiety, mood issues, countering pain and stress, improving sleep quality.

However, combining CBD with other essential oils or adding terpenes to CBD oil provides greater creative freedom to manufacturers. It opens doors to almost endless opportunities to create products for different health benefits.

Although cannabis is accepted as one of the medicinal plants, it is vital to understand that most of its health benefits are mild and occur on prolonged use. These products are not a replacement for any medication or treatment. They are just utilized for added benefits.

To conclude, CBD isolate or broad-spectrum CBD distillate are safe, free from impurities. However, they either lack or have a low entourage effect. Combining CBD with various essential oils and terpenes may help create products with unique aromas and benefits.

Which are Essential oils do you think are best combined with CBD? Mail us your opinions! Or if you are willing to try CBD blended with your desired essential oils, complete the contact form to make an order.

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Exploring the Water Soluble CBD Market

Updated January 15, 2024

Written by

Simon Šfiligoj

CBD Manufacturing

Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

Introducing Water Soluble CBD

Days of offering clients just a CBD oil are over. There is intense competition in the market. Thus, a successful CBD company must offer its clients value-added products. It is also vital to provide a wide range of products.

Differentiating the product from others is the key to success. And offering products with better bioavailability in a greater range may help. For example, water soluble CBD may offer an edge over competitors, helping enhance the range of products.

The Water Soluble CBD Market

The water soluble CBD market is relatively nascent yet. It means that it is the right time to explore this segment. Almost every day, there is news for one or another manufacturing launching its water soluble series in the market.

At present, most launches of water soluble CBD are happening in larger markets like the UK or Germany. However, it is worth understanding that many EU markets like France or Nordic regions will grow quite fast in the near future. As a result, the European CBD market is expected to grow by at least 400% in coming four years.

Water Soluble CBD’s use in the Food industry

Almost all food items require adding water, and only some foods have added oils. It means that water soluble CBD offers innumerable opportunities. Theoretically, it can be added to any food item without any changes to the original recipe.

Did you know that cannabis edibles have been consumed for thousands of years? In India, marijuana-infused sweets and beverages are offered to lord shiva. It is a tradition people have been practicing since the Vedic era, that is, for the last few thousand years. Offering cannabis edibles is a part of rituals. That is why marijuana-based products (full-spectrum CBD with high THC) were never banned in the holy city of Varanasi.

Here are some of the most common water-soluble CBD food items available these days:

Baked goods

Some manufacturers are already producing CBD-infused cookies in small batches. However, due to issues related to shelf-life and specific regulatory challenges, CBD-based baked products are generally made in small quantities for local sales. Therefore, producing a range of CBD-baked products may be a good idea for smaller manufacturers.

Chocolate

Europeans are the largest per capita consumers of chocolates. As chocolate has a good shelf life, there are already many manufactures into it. The good thing is that, quite like regular chocolate, people can use CBD chocolate to make their favorite recipes like brownies, chocolate-dipped cones, and much more.

Gummies & candies

Gummies and candies are among the most common and preferred ways of consuming CBD. They can be produced in innumerable flavors and types. Of course, one may use regular CBD isolate powder or CBD crystals to make them. However, water soluble CBD isolate would provide much higher bioavailability.

Snacks foods

It is another less explored area by manufacturers. Sportspeople love CBD. One may produce CBD-infused energy bars, high CBD hemp protein bars. These are examples of excellent value-added products, as they provide CBD along with other health benefits. One may position their product as something that helps with quicker recovery post-workout, and so on.

Cooking ingredients

On searching the internet, one may readily understand how underexplored this segment is. For those selling CBD products via retail chains, supermarkets, cooking ingredients could be an excellent idea. One may add CBD to various blends of spices, baking powders, and much more.

Condiments

CBD-infused sauces are already making their way to the shelves of certain retail chains.

Water Soluble CBD’s use in the Beverage industry

This is where water soluble CBD excels. After all, one cannot create water-based drinks using CBD oil.

The market trend is usually to create sparkling CBD water/drinks. There could be three options for most manufacturers:

CBD infused energy drinks

It is no secret that CBD is mainly loved for its ability to help fight pain and its calming effect. Such drinks may be targeted towards those living an active lifestyle, though not necessarily. One may even create a pre or post-workout drink.

CBD infused soothing drinks

Many people love the calming effect of CBD. Thus, it is a common idea to create CBD drinks infused with extracts of other calming herbs like chamomile, lavender, ashwagandha. These drinks could be good for countering mild episodes of fear and anxiety. They may also help sleep better.

CBD infused flavored or refreshing drinks

It is the most straightforward approach of adding CBD to commonly used various flavored or refreshing drinks. Such drinks are usually for frequent consumption, and thus only small amounts of CBD need to be added to them.

Water Soluble CBD’s use in the Cosmetic industry

Infusing CBD to cosmetic products helps create cosmeceuticals, products that not only enhance beauty but have some health benefits, too.

Topical use of CBD is supported by science, as there is evidence of endocannabinoid system (ECS) in the skin. Dysregulation of ECS may have a role in eczema, psoriasis, and even skin cancer.

CBD topical products may offer some unique benefits. CBD may help enhance the hydrating, moisturizing, anti-inflammatory effect of some products. In addition, CBD may help reduce skin itching, slow down skin aging, and much more.

Although CBD oil may be used to produce CBD cosmetics, water-soluble may help create non-sticky unique skincare products. Following products good could be a good option to enter the CBD cosmetics market:

Skincare serum

Serum for special skin concerns like acne. CBD may help due to its mild antimicrobial activity and anti-inflammatory action.

Powders

These are generally for preventing skin itching, especially during summer. Such a powder may also help prevent skin allergies caused by certain fabrics.

Makeup cleansers

Makeup cleanser with anti-inflammatory action may be quite an attractive product.

Moisturizers

Moisturizing creams are one of the most commonly used products. However, adding water soluble CBD may have some additional benefits in such products.

Sunburns soothing cream

CBD may help reduce skin inflammation and irritation caused by sunburns.

Massage gel

Oil-based massage creams or massage oils are indeed loved by many, but not all. Some individuals do not like oily skin left after the massage. Water soluble CBD-based oil-free massage gel may be a great option for many.

Lip balm

Water soluble CBD may be especially effective in preventing local irritation, cracking of lips.

Evening skincare gel

Many people like to apply skincare gels in the evening. When skincare products are applied to the skin before going to bed, they have ample time to work.

Shampoo

CBD shampoos are often recommended for preventing hair loss. In addition, CBD may help due to its antimicrobial, antifungal, anti-inflammatory action.

To conclude, the above are just some of the unique ways to enter a highly competitive CBD market. One may procure water soluble CBD isolate or full spectrum water soluble CBD wholesale and start producing some of these products.

Cosmetics, food, or beverages? Let us know where you think water soluble CBD shines the most. And to make your water soluble formulations happen, contact us on this page.