Category: CBD

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How CBD & Immune Systems Interact

Updated January 15, 2024
Written by
dr. Preet Sal SB
CBD Health Benefits
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

The human immune system is quite complex, and it saves the body from invaders like bacteria, viruses, and fungi. It also helps in tissue repair and may also help eliminate toxic substances from the body.

It is quite a complex system containing specialized organs, cells, and proteins. The human system is continually growing and upgrading. It is created in the bone marrow, may mature in various organs, travel through a dedicated highway called the lymphatic system, and quickly acts where needed most.

If some threat is detected, it initiates a defensive response in many ways. It may attack and kill the invading microprobe, create proteins that kill the invading microorganisms, and more. It also releases messenger proteins to get support from various organs. Thus, it plays a vital role in inflammation and tissue regeneration.

The immune system contains two parts: the innate immune system with which a person is born and the adaptive immune system that develops throughout life. Both these immune systems share information with each other and work together to protect the human body.

Some organs that play a vital role in its development are bone marrow, lymph nodes, adenoids, spleen, thymus, and tonsils.

Although primarily protective, it is also prone to errors. For example, sometimes, it may hyper-react, causing allergic reactions and damage to the body. Similarly, it may also sometimes initiate inflammation responses that do more harm than good. Thus, a need to tweak and modulate human immunity.

CBD has many health effects, and many of its benefits are due to its influence on the immune system.

CBD and immunity

How CBD & Immune Systems Interact

Considering that the immune system is quite complex, it isn’t easy to understand how it interacts with immunity. Nonetheless, science is still trying to understand how it may help the human immune system.

CBD is not a nutrient, but it can modulate various receptors, enzyme systems, and organs and thus ultimately change the immune responses.

Perhaps the most important way it acts is due to its effect on the endocannabinoid system. It appears that CBD is structurally close to intrinsic endocannabinoids, and thus it may affect endocannabinoid receptors present throughout the human body.

Before discovering the endocannabinoid system, researchers were genuinely struggling to explain how CBD may affect the immune system. Medical researchers could see that CBD can alter immune responses, but they could not explain how it works. Unlike another compound in cannabis, THC, CBD does not have potent mind-altering properties.

However, it may alter immune responses by modulating the working of endocannabinoid receptors present throughout the body. Now science shows that endocannabinoid receptors are not just present in the brain but also in every organ from the gut to the skin.

CBD can modulate the activity of CB1 receptors that are primarily found in the brain and CB2 receptors that are more abundant in various body organs.

However, there are other ways in which CBD may affect the immune system. For example, studies show that it can act as an antioxidant and thus help change the body’s redox balance. Now researchers think that its ability to modulate redox balance plays a critical role in its anti-inflammatory properties.

Does CBD Help Immune System Response?

CBD can alter immune responses. The immune system has many complex functions in the body. Thus, sometimes it appears to suppress immunity, while it seems to modulate immune responses in other instances.

However, one should not be worried about hearing that it may also suppress immunity. Most anti-inflammatory medications work by suppressing certain functions of immunity. Similarly, CBD also reduces some overactive parts of the immune system.

Of course, since it can suppress immunity, it is pretty good for reducing pain and inflammation. However, quite like other anti-inflammatory drugs, one should be careful using CBD when there is a high risk of catching an infection.

Nonetheless, it is more likely to modulate immune responses, as visible by its effect on various disorders. In addition, it means that it is more likely to suppress only specific immune responses selectively. Thus, it would not increase the risk of seasonal infections or make a person prone to certain diseases.

Perhaps the best way in which CBD helps the immune system is by suppressing hyperinflammatory responses. Thus, it is good for conditions like joint pains. Additionally, it may also lower systemic inflammation, and help prevent disorders caused by low-grade inflammation like heart diseases or neurodegenerative disorders.

New studies show that it may alter certain immune responses more than others. Although researchers are not sure how it happens, they think that its ability to suppress certain parts of immunity selectively may significantly help in some conditions. Thus, early experimental studies show that CBD may help prevent type 1 diabetes, an autoimmune disorder.

Studies suggest that the endocannabinoid system and cannabinoid receptors are involved in the development of autoimmune disorders. It also means that suppressing specific immune responses and modulating the working of CB1 and CB2 receptors may be particularly helpful in autoimmune conditions.

CBD and immune system

List Some Ways CBD Interacts with Immunity

In this article, we have already mentioned many ways in which CBD may interact with immunity. CBD may not boost the immune system, but it may help fine-tune immune responses. Thus, it can help in many disease conditions.

The most important way in which it interacts with immunity is through its influence on the endocannabinoid system and its ability to modulate CB1 and CB2 receptors. These receptors are present in all immune organs, from bone marrow to the lymph tissues.

Some of the effects of CBD on immunity are indirect. Like it may promote the working of other internal organs and thus help normalize immunity.

There is no doubt that another significant interaction pathway is its effect on redox balance. In addition, CBD can boost the body’s antioxidant ability and thus help alter immune responses.

Further, some of its influences on immunity may likely be due to its effect on brain health. For example, it may alter immunity by reducing stress, lowering the level of stress hormones, and much more.

Benefits of CBD As an Immunosuppressant

Most people do not realize that significant overexpression of certain parts of the immune system is a significant problem. This is because the immune system often wrongly starts targeting various body parts or overreacting. This is visible in conditions like inflammatory disorders of joints or autoimmune diseases.

Consequently, there could be many benefits of the mildly suppressing immune system with the help of CBD. Moreover, unlike medications, its action is much more subtle and selective. Pharmacological immunosuppressants are highly toxic, causing suppression of even beneficial immune cells.

However, unlike medications, CBD only suppresses some overactive parts of the immune system through the endocannabinoid system. It is more like a balancing act. Thus, it would not suppress the immune system significantly, but only enough to help in a range of disease conditions.

Due to its ability to suppress immunity, CBD may help with inflammation. Therefore, it is suitable for autoimmune conditions like type 1 diabetes, multiple sclerosis, lupus, allergies, and much more.

What is good about CBD is that it also has many other health effects. Hence, it not only helps overcome autoimmunity but may also help counter some of the autoimmunity-associated problems like spasticity, skin irritation, pain, mood swings, and much more.

Final thoughts

CBD can influence the immune system in many ways. Firstly, it may directly influence the working of immune cells, alter the activity of immune organs, and may also help due to its effect on the body’s redox system. Moreover, CBD is safe for prolonged and regular use. It may suppress only overactive parts of the immune system and thus help in allergies, inflammation, and autoimmunity without posing any health threat.

If you are interested in learning more about CBD or want to help people living with immune disorders, we have many CBD products.

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What Are Some Lesser-Known CBD Health Benefits?

Updated January 15, 2024
Written by
dr. Preet Sal SB
CBD Health Benefits
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

For those skeptical about CBD and its health benefits, it is good to know that humans have traditionally used cannabis to treat health disorders for thousands of years. However, it was wrongly banned in the mid-20th century over the worries of addiction and harm to health.

Fortunately, medical experts started realizing their mistakes by the end of the 20th century. They understood that CBD is relatively safe and suitable for health. In addition, science revealed that most harms and addictions are due to THC in cannabis, and removing THC from CBD products makes any cannabis product highly safe to consume.

Some Lesser-Known CBD Health Benefits

Those who still disbelieve in CBD need to understand that there are already few approved medical drugs based on CBD. It is good to treat resistant epilepsy in children, rare autoimmune neurological disorders, have a calming effect, and may also help with some mental health issues. Thanks to extensive clinical research into the subject, the list of its benefits is fast expanding.

In recent years, there has been increasing interest in finding natural remedies for metabolic disorders and some less common diseases. Studies show that CBD can help in the least expected way. Thus, it could be good for gut health, alter immune responses, fight infections, manage autoimmune disorders, suppress inflammation, etc.

It is impressive that CBD also appears to be good for conditions like diabetes, rheumatoid arthritis, substance abuse disorder, weight loss, and even more.

lesser known CBD benefits

What Are Some Well-Known Health Benefits of CBD?

Seizures

It could be regarded as one of the less unexpected benefits of CBD. But now, studies show that CBD is quite suitable for controlling seizures when used along with other treatments.

Even more striking are the findings indicating that CBD is especially good for resistant epilepsy. Moreover, these are the patients who failed to get benefits from some of the best pharmacological drugs. However, adding CBD to treatment may considerably reduce seizure rates.

Studies show that adding CBD to traditional anti-epileptic therapy in those resistant to other treatments may benefit about half the patients (49%), which is much higher than placebo. Thus the study leaves little doubt about its efficacy.

Therefore, US FDA and European Medical Agency (EMA) have even approved CBD-based medication called Epidyolex to manage this rare kind of resistant seizure disorder.

But that is not all; amazingly, it is approved for use in children. This only shows that CBD is relatively safe for use in different age groups.

Pain

It is another area of interest. People have traditionally used cannabis or marijuana to manage severe and chronic pains. Of course, CBD is different from cannabis or marijuana, but it seems to retain some of its pain-killing action. In addition, it appears that broad-spectrum CBD is more effective in pain management than CBD isolate.

When using CBD for pain, one is not expected to use it alone and instead as a part of broader therapy. Thus, it may be combined with other medications and pain killers, and it will potentiate their action.

Diabetes

Again, do not expect CBD to prevent or manage diabetes alone, as it is not a magic pill. However, it can be pretty good when used along with other efforts, lifestyle interventions, and medications.

Studies show that it can modulate metabolism and appetite and reduce insulin resistance. Thus, regular intake of CBD may help prevent diabetes in a high-risk individual. It is also beneficial for those living with mild to moderate diabetes.

Diabetes is quite a complex disorder, and CBD can help in multiple ways. For example, CBD may help lower the risk of various diabetes-associated complications. In addition, it may help both due to its mild glucose-lowering action and its ability to reduce bad cholesterol, reduce chronic inflammation, and help regulate insulin secretion.

Not only that, those living with diabetes are prone to neuropathies, and CBD may help prevent and manage nerve disorders. It may be good for preventing diabetes retinopathy, too.

Neurodegenerative diseases

Do not expect CBD to treat Alzheimer’s or Parkinson’s. However, CBD can help reduce the risk of these ailments on prolonged use. It may have a role in slowing down the progress of these disease conditions. Additionally, it may also help manage some of the symptoms of neurodegenerative disorders.

Studies suggest that CBD may help in many ways. It can lower inflammation, alter immune responses, and may also help due to antioxidants. Further, it benefits due to its impact on the endocannabinoid system and modulating CB1 and CB2 receptors. Studies show that it may also influence cellular energy production, increase the production of neurotransmitters, and thus help in multiple ways.

Multiple sclerosis (MS)

MS is a chronic and a pretty common autoimmune disorder of the brain. It is highly challenging to treat. Some people do not respond to immunomodulatory therapy. Even worse, immunomodulatory drugs are highly toxic. However, CBD may help as an addon therapy by modulating immune responses1.

But that is not all, and it appears that CBD may also help tackle some of the symptoms of MS. Thus, it may help reduce MS-associated spasticity.

CBD is so good for managing MS that EMA has already approved CBD-based medications to help those living with MS. It is a medication called Sativex.

Anxiety

Anxiety is the most common emotional disorder that affects most people sometimes in their lives. Since it is such a common health issue, people often use natural supplements to manage the condition. Studies show that CBD may be good to use in mild to moderate anxiety. It may help overcome worries and fears.

Depression

Depression is another common mood disorder. It may even coexist with anxiety. Although there are many medications to manage depression, they are highly toxic. Moreover, studies show that pharmacological drugs only work in severe depression, but they fail to help in mild to moderate cases. Therefore, studies suggest that CBD could be one of the better and more natural ways of managing depression.

Insomnia

Sleep disorders are on the rise. They are now considered an independent risk factor for various ailments. It appears that people are not only sleeping less, they also have poor sleep quality. Further, the use of gadgets is making things worse. Many people may lie in bed for long, but they do not sleep enough.

Sedative drugs may help initiate and maintain sleep, but they alter the sleep architecture. Thus, people taking sleeping pills do not wake up feeling fresh the following day. However, CBD does not alter sleep architecture and works mildly.

Inflammation and Autoimmunity

Low grade or so-called silent inflammation is among the significant cause of the chronic disorder. It appears that CBD may not only help subdue inflammation but may have a role in altering inflammatory responses. Thus, CBD may help prevent flares of autoimmune conditions, too.

Acne

Many countries now allow CBD supplement producers to claim that their product is anti-sebum and may help prevent acne. There is emerging evidence that CBD may play a vital role in managing acne. It helps both due to its ability to reduce sebum production and its anti-inflammatory properties. In addition, it is quite likely that it may help due to other mechanisms. CBD work by modulating the endocannabinoid system that is present widely in the skin.

cbd health benefits and lesser known effects

Is CBD an Anti-Inflammatory?

Yes, it works. In recent years researchers have discovered many mechanisms in which CBD may work. CBD can bind to various receptors and alter inflammatory responses. It seems that CBD is suitable for both local acute inflammation like that found in joint pains and low-grade inflammation that causes chronic disorders. It may also help in autoimmune conditions due to its anti-inflammatory properties.

Is CBD Antifungal?

CBD oil can exert potent antifungal infection in many ways. Generally, most oils have mild antifungal properties. However, new studies now suggest that CBD has direct antimicrobial properties. Thus, it may help both when used orally or applied topically.

However, it may not help in severe systemic fungal infections and is more likely to help well with some localized fungal infections. Nonetheless, there is a need for more studies to explore its role in controlling fungal infections.

Does CBD Oil Have Antibacterial Properties?

CBD has mild antibacterial properties. It works in multiple ways. It has some direct antimicrobial action. However, it may also work due to its influence on immunity, ability to reduce inflammation, and much more

To conclude, CBD is no panacea, but it can definitely help with many health conditions. People have traditionally used CBD to manage all kinds of disease conditions. Some of its benefits, like those in pain, anxiety, and seizures, are well known. However, new studies show that it may also help lower inflammation, help in autoimmune conditions, normalize metabolism, and may even help prevent and manage infectious diseases. It is pretty likely that many of its benefits are still waiting to be discovered.

Those interested in starting their CBD business or interested in creating unique CBD products for various health conditions can contact us. You can also learn more about CBD oil health benefits here or buy CBD products wholesale.

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What is Leaky Gut Syndrome & how can CBD affect it?

Updated January 15, 2024
Written by
dr. Preet Sal SB
CBD Health Benefits
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

It is said that all disease begins in the gut. Nonetheless, science struggles to understand the relationship between gut health and many malaises. In addition, studies show that almost every second person visiting the doctors due to gut issues has very vague complaints.

They may complain about mild abdominal discomfort, bloating, constipation, diarrhea, headaches, fatigues, sleep issues, and yet these individuals might be relatively healthy.

Experts now call these difficult to diagnose conditions as functional gastrointestinal disorders. The most common diagnostic tests would be close to normal in these conditions. Yet, a person would have multiple and difficult to explain complaints.

A leaky gut syndrome is a term more frequently used by traditional medicine practitioners than doctors. Nevertheless, in recent years, many doctors are also accepting that leaky gut syndrome exists.

What is Leaky Gut Syndrome?

A leaky gut syndrome is a term to describe altered gut permeability. Many medical experts believe that it is a widely prevalent condition. It is present in almost all gastrointestinal disorders, particularly in functional gastric diseases.

There are many reasons why gut permeability changes. It could be due to a damaged upper protective layer of the gut. However, that is not all, and leaky gut syndrome may also occur due to changes in gut mucous production, which plays a vital role in intestinal barrier function.

Additionally, researchers think that there are many other causes for the leaky gut syndrome, like altered local immune responses, inflammation, and even changes in the gut microbiota.

It means that leaky gut syndrome is present in almost all gastrointestinal disorders. These changes in gut permeability have many health consequences like poor absorption of nutrients, greater absorption of toxins, penetration of pathogens through the gut wall, and much more.

leaky gut syndrome

What Causes Leaky Gut Syndrome?

Researchers are still struggling to understand what causes the conditions like leaky gut syndrome. However, they are sure that it occurs due to many reasons, and thus the challenges in managing such health disorders. In fact, science still does not fully understand its underlying mechanism, though there are many hypotheses.

One reason for a leaky gut could be a gastrointestinal infection. However, it is not among the most significant causes. It appears that in most cases, leaky gut syndrome occurs due to non-infectious reasons.

Thus, for example, changes in gut microbiota and local immune responses could be among the most significant cause of the leaky gut syndrome. This is also proven by the fact that normalizing gut microflora has a beneficial effect on chronic gastrointestinal disorders.

However, there are many other poorly understood causes like autoimmune reactions. It appears that autoimmune diseases are also emerging as one of the most significant causes of gut disorders.

Another emerging understanding in medical science is the role of brain health in maintaining gut permeability. It means that mental stress, mood disorders may also lead to leaky gut syndrome.

Is Leaky Gut Syndrome related to Brain Health?

Mechanisms underlying the “gut feeling” are now more or less understood. It appears that emotional swings, anxiety, fear, and stress cause changes in gut mobility through increased sympathetic nervous system activity.

Generally, the gut can recover quickly from gastrointestinal issues caused by acute stress. However, chronic stress is altogether a different thing. Chronic stress causes changes in gut motility and gut defenses, thus leading to leaky gut syndrome.

A leaky gut syndrome caused by chronic stress is challenging to identify due to the subtle nature of signs and symptoms. Although signs of such a disorder tend to be less severe, they are chronic. It means that a person continues to live with altered gut function, bloating, fatigue, abdominal pain, etc.

It is unwise to think that only stress or anxiety causes the leaky gut syndrome. Even other brain disorders like Alzheimer’s, Parkinson’s, and even psychotic conditions may alter gut function considerably.

What is more worrisome is a discovery that there is a bidirectional relationship between the brain health gut – something researchers now call “the gut-brain axis.” It means that gut health influences brain health and vice-versa.

Studies show that the vagal nerve innervating the gut carries more information from the gut to the brain than the other way, as thought earlier. Similarly, studies show that one of the most vital neurotransmitters in controlling mood that is serotonin is primarily produced in the gut. Studies estimate that almost 90% of serotonin is produced in the gut.

That is not all; the gut produces many neuroactive compounds, peptides, and much more. Similarly, the brain exerts significant control over gut health.

It means that altered gut function has an ill effect on brain health, and brain issues cause changes in gut health, thus forming a vicious circle. It means that to manage the leaky gut syndrome, one needs to break this vicious cycle.

How to use CBD for Leaky Gut Syndrome

Both the local intestinal changes and altered brain function may lead to a chronic health issue like leady gut syndrome, and CBD may help in multiple ways in the condition.

CBD can influence local endocannabinoid receptors in the gut and the brain’s endocannabinoid receptors. Studies show that CB1 receptors are abundant in the brain and CB2 in peripheral tissues, including the gut. CBD oil acts on both receptors.

Thus, by acting on CB1 receptors in the brain, CBD can help counter anxiety, reduce stress, improve sleep, help regularize gut motility, and therefore positively impact gut health.

Similarly, CBD’s action on CB2 receptors improves gut function and reduces gut permeability, thus helping overcome leaky gut syndrome.

Can CBD help with Leaky Gut Syndrome?

Yes, CBD can help with the leaky gut syndrome. However, lots would depend on the cause of the condition. In some cases, the benefit could be dramatic.

CBD will not help if the cause of the leaky gut syndrome is an infectious disease or small intestinal bacterial overgrowth (SIBO).

However, it would be pretty beneficial when it is secondary to prolonged stress and anxiety. It may be especially good for irritable bowel syndrome, inflammatory bowel disease, and functional diarrhea or constipation.

It may help both due to its calming effect on the brain and also due to its ability to alter immune responses.

Since functional gastrointestinal disorders tend to be chronic, one can expect more significant benefits on prolonged use for 8 to 12 weeks.

If you are into the CBD business and want to learn more about the role of CBD products in gastrointestinal health, you can contact us.

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What is the Gut Microbiome & how can CBD affect it?

Updated January 15, 2024
Written by
dr. Preet Sal SB
CBD Health Benefits
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

For long researchers have visualized the gut merely as a long pipe-like organ where digestion of all foods happens. However, this concept has entirely changed in recent years, as researchers realize that gut health has a much broader role in human wellbeing.

It is not evident that the gut not only digests food but it also produces thousands of bioactive compounds, hormones, neurotransmitters, vitamins, and much more. In addition, the gut plays an important role in immunity, mood, and brain health.

Now researchers fully realize the meaning of “gut feeling” and all its complexity. In addition, they recognize the complex association between the brain and gut, which they now call “the gut-brain axis.”

Just consider the fact that the human gut produces 90% of serotonin, it has most neurons outside the brain, it has more nerve fibers moving from gut to brain than the other way. So, it means that the gut is playing a greater role in brain health than ever imagined.

It is really difficult to believe that gut is so complex, with trillions of microbes living in it and having so many neurons. Moreover, gut neurons are quite similar to those in the brain and use very similar neurotransmitters. Thus, experts have even gone further by calling the enteric nervous system “the second brain.”

What is the Gut Microbiome?

Before we dive deeper into the subject, let us look at the two related concepts: microbiota and microbiome. Although they might be used interchangeably, these are slightly different terms.

Gut microbiota means all the microbes that reside in the human body. They are mainly bacteria and yeast. On the other hand, microbiome means combined genetic material of all the bacteria and yeast living in the human body.

Experts estimate that trillions of bacteria and yeast live in the human body. There are almost as many microbial cells in our body as human cells. The estimated weight of these microbes is a few hundred grams in an average human. Together, these microbes living in the human body have an estimated ten times more genetic material than human cells.

Since there are so many microbes residing in the human body, they might be playing some vital role in human health. It appears that more than 80% of these microbes reside in the gut.

New studies suggest that gut microbiota or microbiome changes may play a vital role in various disease conditions, including brain and mood disorders. It also means that tweaking the gut microbiome may help alter brain health and even function.

gut mcrobiota

What affects the Gut Microbiome?

The human microbiome is changing fast, and it is a cause of severe concern. Trillions of microbes live in symbiosis in the human gut. They produce so many beneficial compounds, and any alterations in their population would be devastating for human health.

So, what is affecting the gut microbiome? That is perhaps not very difficult to guess. Human lifestyle and environment have changed more in the last century than for thousands of years.

One reason for changes in the gut microbiota is the changing environment. Environmental pollutants, toxins, enter the human body in various ways, and they negatively impact the microbiome.

However, the greater reason for changes in the microbiome is changing dietary patterns. After all, more than 80% of microbiota resides in the gut. The human diet has changed completely in less than a century. Moreover, it is now abundant in preservatives, colorants, and other chemicals.

Additionally, medications have also played an important role in changing gut microbiota. For example, antibiotics can eradicate vast populations of gut microbiota, thus making significant microbiome changes. However, at present, very little is known about the long-term effects of these changes in the human microbiome.

These changes in the microbiome are not only due to antibiotics. People these days are living with so many chronic disorders and taking so many other medications on a daily basis. But unfortunately, most medications are highly toxic to microbiota.

Further, dietary changes like low consumption of dietary fiber, high consumption of fast-absorbing carbs, ultra-processed foods also alter gut microbiota.

How does the Gut Microbiome influence Human Health?

Science still has a very limited understanding of how the gut microbiome influences human health. It is due to the very complex nature of the subject. Nonetheless, it appears that the microbiome influences almost every parameter of human health.

For example, colonization of the human body starts immediately after birth. Thus, researchers think the microbiome plays a vital role in early immune system training. Hence, changes in the microbiome may not only weaken immunity but may also contribute to autoimmune disorders.

Similarly, the role of the microbiome in gut health is well known. Hence, any changes in the gut microbiome lead to severe disease conditions like inflammatory bowel disease (IBD) and infectious colitis.

It means the microbiome plays a vital role in infectious and non-infectious diseases, as it produces many important bioactive compounds. In addition, conditions like IBD occur due to severe changes in the immune responses.

However, an increased risk of gut infection occurs due to the reduced population of good bacteria in the yeast. These good bacteria prevent the overgrowth of harmful microbes in the gut.

Can the Gut Microbiome affect Brain Health?

Trillions of microbes living in the gut appear to produce many beneficial and complex compounds. Science now understands that without these compounds, human survival is not possible.

However, what is interesting is the vast array of neuroactive compounds produced by the gut microbiome. Thus, it appears that the gut microbiome has a big say in brain functioning and brain health.

Studies show that the gut microbiome produces almost all the vital neurotransmitters like serotonin, dopamine, acetylcholine, norepinephrine, and GABA.

Since the gut microbiome produces so many neurotransmitters, it is logical to conclude that they play a vital role in brain health. In addition, it is now evident that changes in the gut microbiome influences mood, cause anxiety, depression, and other issues.

What is even more worrisome is that changes in the gut microbiome might be responsible for the emergence of complex degenerative brain disorders like Alzheimer’s and even multiple sclerosis.

gut microbiome

Can CBD help the Gut Microbiome?

CBD is known to influence brain health. It now appears that many of its effects are due to CBDs’ influence on the gut-brain axis.

Almost everything that we ingest influences the gut microbiome in one way or another. However, bioactive compounds like CBD have a greater influence. These influences on gut microbiota could be due to CBD’s impact on the digestive system, immune system, and nerve endings.

Other ways in which CBD may help is by altering the enteric immune system, reducing gut permeability, reducing local inflammation, and directly regulating gut bacterial. It appears that many long-term effects of CBD might be due to its impact on the microbiota-gut-brain axis (MGBA).

Some of the CBD’s effects on gut microbiota are due to its impact on local endocannabinoid receptors. This helps normalize gut permeability and motility and has a calming effect on the gut. This ultimately promotes the growth of beneficial gut microbes.

Here it is vital to understand that CBD would not directly impact gut microbiota like probiotics or prebiotics. Instead, it would influence more by regulating local inflammatory responses and even regulating microbiota and thus helping alter the microbiome.

To conclude, the gut microbiome plays a vital role in human health and brain health. CBD is also known to have multiple effects on brain health. Therefore, it is pretty likely that many of the CBD’s effects may be due to its impact on the gut microflora. At present, experts know little about the role of CBD in modulating the gut-brain axis through its impact on the gut microbiome. However, future studies are quite likely to improve understanding in this direction.

If you want to know more about how CBD may help improve gut health and microbiome, what products are especially good for it, contact us.

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Effective CBD Skin Care Products: What’s Out There Now?

Updated January 15, 2024
Written by
dr. Preet Sal SB
CBD Health Benefits
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

CBD is not just about body aches, mood, or other body disorders. Several beauty products use CBD for its perceived benefits. And, remarkably, emerging research shows that it may have some unique advantages for skin care.

Thus, it is no surprise that cosmetics producers add CBD to skin care cosmetics, creams, moisturizers, balms, body lotions, and every conceivable cosmetic item.

Experts think it is perfect for reducing sebum production, preventing oily skin, managing acne, and even preventing skin hyperpigmentation. Additionally, CBD helps reduce skin inflammation and may have some hydrating effects.

Another benefit of adding CBD to skin care products is reduced skin irritation and increased resilience to environmental toxins. It may even help with some allergic conditions, too.

CBD Skin Care Products In 2022: What’s Out There Now?

Although there are many CBD products for every need, CBD-infused cosmetics generally cost little more than regular cosmetic products. Thus, reasonably, users want to learn about the added benefits of using such products.

Hence, new CBD products are all about added benefits. They generally belong to the class called cosmeceuticals. These are cosmetics that can even manage some skin disorders or chronic problems. Thus, a person buying CBD cosmetics expect a little more, like reduced fine lines, lesser skin irritation, help with skin inflammation.

However, once the user has experienced the benefits of a specific CBD cosmetic brand, they are likely to stick with it for long. Thus, CBD cosmetics often have greater brand loyalty.

CBD-skincare

How Does CBD Work on Your Skin?

Almost every second person is living with skin issues. Moreover, skin aging is unstoppable, but most would like to slow it down. Skin issues are caused both by some local skin problems and systemic diseases. Thus, metabolic disorders and gut diseases may also affect skin health.

There is considerable research showing that CBD may help in some conditions.

Reduces inflammation and helps with eczema

CBD acts on CB1 and CB2 receptors present throughout the body. However, CB2 receptors are especially in abundance in the skin. Thus, it may help alter immune response, suppress inflammation, help get rid of allergies. Hence, CBD helps suppress inflammation and may benefit those living with eczema.

Reduces oil production

CBD acts on both nerve endings and oil-producing glands in the skin. Thus, it helps normalize skin oil production. What is good about it is that it does not cause skin drying or irritate the skin. Therefore, it is suitable for prolonged use, too.

Helps manage acne

Acne is a significant problem in many population groups. It is challenging to manage due to many factors. It is caused by hormonal changes, infection, inflammation, the hyper-reactive response of the skin, and much more. CBD is sebostatic and anti-inflammatory. Thus, it lowers skin inflammation and, at the same time, reduces sebum production, resulting in considerable benefit in acnes.

Have a soothing action

Some people like the soothing action of topical CBD that may last for a few hours. They might not have any severe skin conditions, but these are the people who dislike the way their skin feels. So, CBD is not just about managing skin disorders. It is also about a unique experience.

Prevent damage due to free radicals

Quite like other natural extracts, CBD also possesses antioxidant capacity. Thus, it helps neutralize free radicals. As a result, it may have a role in reducing photodamage to the skin. It also helps slow down skin aging.

Hydrating effect

CBD helps keep skin hydrated. These actions are due to the direct effect of cannabinoids and other hydrating components in various cosmetic products.

CBD and skincare

What Forms Can CBD Skin Care Products Take?

With so many fabulous CBD-infused cosmetics, it could be pretty challenging to understand the range of CBD products available. It is a challenge both for consumers and those planning to start selling their range of products. However, learning a bit more about various CBD products may help.

You can start by checking our skincare products HERE.

CBD Skin Cream

Creams should be in the cosmetic box of every home. They are helpful for various purposes like improving skin moisturizer, helping with eczema, reducing skin irritation, keeping it hydrated, reducing fine lines. Thus, one should choose a cream that has multiple antioxidants along with CBD, like flavonoids, polyphenols, and many more. Creams are generally a bit thick in their consistency. There are general-purpose skin creams like face and body cream by SpakeNK. Or creams for more specific needs like CBD replenishing eye cream by dermaquest. Similarly, there are creams for hands, nails, feet, and more.

CBD Body Lotion

Unlike facial creams, body lotions are good in the way that much of the CBD enters the bloodstream as absorbed via the transdermal route. Thus, they have much broader health effects. For example, one can buy a nighttime or body lotion for relaxation, with the benefits of magnesium, arnica, argan oil.

Or one can also opt for a body lotion that can help with sore muscles and tiredness, which comes with organic menthol and jojoba seed oils.

CBD Body Butter

CBD body butter is all about creamy, nourishing, something that has the benefits of CBD along with the benefits of other herbs, almonds, shea butter. It is to delight your body, soothe, and rehydrate. It would absorb within minutes and help sore and broken skin. Although one does not need to use it daily, even using it a few times a week may make a significant difference. One such excellent product is from CUBID CBD.

CBD Balm

When you think of balm, you immediately think about something with a soothing action that can relieve muscular pains, improve mood, help with achy joints, and reduce stress. But how about trying a CBD-infused balm? It means the benefits of a regular balm and added calming and pain-relieving action of cannabinoids. Additionally, added terpenes can provide health benefits and enhance their healing properties. Therefore, If you are looking for a CBD balm, check out this balm from KLORIS.

Final thoughts

CBD products now come in almost every conceivable form. It is because CBD is quite simple to add to various cosmetic products. As a result, manufacturers even do not need to change product formula. Instead, they might add CBD to their already existing range of products. Moreover, both oil and water-soluble CBD isolate, and distillate is available these days.

If you have any queries, want to start your own CBD cosmetics business, or have questions about how can CBD cosmetics fit into your business, contact us.

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7 minute read

CBD vs. Hemp Skin Care Products What’s The Difference?

Updated January 15, 2024
Written by
dr. Preet Sal SB
CBD Health Benefits
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

Now that CBD is legal in most parts of the world, and its topical application, more and more skin care products using CBD or hemp would continue to emerge in the market. However, understanding the difference between various terms could be pretty tricky.

Nevertheless, knowing the difference is essential for choosing the right kind of product. For example, when it comes to health benefits or benefits for skin care, CBD-containing products may differ quite a bit from hemp skin care products.

These two do share lots of similarities, and yet they are different. That is why there is so much confusion around it. Here we will explain all the possible similarities between the two and the differences. We will also discuss the advantages and disadvantages of each.

Aren’t CBD & Hemp Skin Care Products Essentially the Same Thing

Theoretically, they might be the same, but that is rarely the case in practice. So first and foremost, it is essential to understand that all these are products of the Cannabis Sativa plant. Both CBD and hemp are extracts of the same plant but different parts.

Traditionally, all cannabis plants have been divided into two groups; hemp and marijuana. Hemp has been used to produce industrial products, fibers, and foods and is low in THC (less than 0.3%); therefore, it does not cause euphoria. Marijuana is just any cannabis plant species high in THC that causes euphoria, and people use it primarily for recreational purposes, though sometimes for medicinal reasons.

It means that all cosmetic products contain hemp extracts and not marijuana. It is because hemp is legal to grow in most nations, including the EU.

However, legally grown hemp also contains minute amounts of THC, along with 100s of cannabinoids. However, the concentration of cannabinoids varies in different parts of the plant. Thus, CBD extract is from the plant’s flowers, leaves, and stalk.

On the other hand, the word hemp means hemp seed oil in most cases. Hemp seed oil is naturally deficient in THC, low in cannabinoids, but rich in other phytonutrients like omega-3 fatty acids and other antioxidants.

So, despite both the CBD and hemp seed oil coming from the same plant, they are the extracts of different parts of the plant, with different chemical compositions and health benefits. Thus, their role in skin care also differs.

There are hundreds of cultivars of the Cannabis Sativa plant. Generally, most countries maintain a list of low THC plants that are legal to cultivate. For example, the EU commission has its list of cannabis Sativa plants varieties, and one can grow these cannabis plants legally in the EU.

hemp-cbd-skincare

Hemp vs CBD Skin Care: The Similarities

Though quite a different thing, nonetheless, CBD and hemp skin care products might share many similarities. Hemp skin care products mean hemp seed oil with omega-3, omega-6 fatty acids, and other antioxidants. Hemp seed oil only has traces of CBD or other cannabinoids.

CBD skincare would still use some type of carrier oil that may also contain omega-3 and antioxidants.

Thus, it would be correct to say that both hemp and CBD skin care products would be oil-based, have a moisturizing effect, reduce skin irritation, and boost skin barrier function.

Both are similar in that they are by-products of the hemp plant or so-called cannabis plant species that predominantly contain CBD and are extremely low in THC.

The good thing about legally grown cannabis/hemp plants is that every part of them has some use and industrial value.

White Label CBD Skin Care

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Hemp vs CBD Skin Care: The Differences

Though both hemp (seed oil) and CBD are extracts from the same plant, they are extracts of different plant parts, thus making them quite different products.

CBD skin care products would be rich in cannabidiol, and they might or might not have other components. Manufacturers often would produce it using either CBD isolate, which is 99% pure CBD. Or they might use CBD distillate, which contains other cannabinoids and is a broad spectrum.

On the other hand, hemp or hemp seed oil does not contain any CBD at all. Even if it contains CBD, it is present in traces. However, it does contain omega-3 fatty acids and other antioxidants. Additionally, it has all the benefits of plant oil for the skin.

It would be correct to say that these are very different products. It would be wrong to call hemp seed oil a CBD skin care product. It is just a kind of plant oil extracted from cannabis plant seeds. Thus, those looking for the benefits of CBD must avoid hemp skin care products. However, hemp seed oil also has uses in skin care, something one should keep in mind.

List Some of the Key Differences

The critical difference between the two is that CBD skin care products must contain CBD (cannabidiol) as an active ingredient. Although, it may also include some other components.

Hemp word indicates that cosmetics contain hemp seed oil, which is naturally CBD and THC-free. Though it may contain traces of cannabinoids due to cross-contamination, the significance of such small amounts of cannabinoids is unclear.

The hemp seed oil has all the benefits of healthy plant-based oil for the skin. In addition, it is rich in omega fatty acids along with other antioxidants. Products made using CBD isolate may not have these benefits.

Thus, CBD and hemp cosmetics are pretty different; hence both may have various benefits in skin care.

There is another crucial difference worth noticing between the two. It appears that generally, the female cannabis plant grows longer, producing large buds. However, male plants have lots of seeds and fiber. Thus, most CBD comes from female plants. However, hemp seed oil and hemp fiber for industrial use come mainly from male cannabis plants.

Additionally, it is worth understanding that CBD cosmetics might have some legal issues in some nations. For example, the manufacturer of such products would need to prove that their product is unfit for consumption, and it is free from THC or only contains it in traces.

From the legal point of view, hemp skin care products are simpler to market and sell. They require fewer documents, and hemp seed oil is legal almost everywhere in the world.

hemp-CBD
hemp or cbd, what is better for skincare

Hemp vs CBD Skin Care Products: Which Is Better for My Skin

Both hemp and CBD skin care products are suitable for skin. However, their benefits may differ. CBD health benefits for skin are quite different compared to hemp skin care benefits.

CBD’s health benefits for the skin include its ability to reduce sebum production and exert potent anti-inflammatory action. Thus, CBD for skin is good for preventing and managing acne. CBD cosmetics are also suitable for those living with anxiety and inflammation.

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Retail-ready formulas not your type? Reach out and develop your own custom formulation.

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CBD cosmetics work by affecting the endocannabinoid system (ECS). ECS may also stimulate regenerative processes in the skin, thus helping in skin irritation and boosting healing processes. In addition, CBD products also exert antioxidant action.

Since hemp does not contain CBD or THC, it works quite differently. Hemp skin care products contain cold-pressed hemp seed oil. This oil is exceptionally nourishing for the skin. It is rich in omega-3 fatty acids, suppresses bacterial growth, boosts skin barrier function, reduces the effects of environmental toxins on the skin.

What is hemp vs. CBD skin care? To conclude, CBD cosmetics may have some benefits in specific skin conditions like acne. It is also suitable for managing oily skin. Additionally, the skin absorbs some CBD, resulting in reduced anxiety and having a calming effect.

On the other hand, hemp has all the nourishing benefits of plant-based oil. In addition, it may be suitable for dry skin.

Both CBD and hemp cosmetics may be good for skin allergies and conditions like atopic dermatitis. Both can exert a soothing effect, reduce inflammation, and suppress allergic reactions.

To sum up, hemp vs. CBD skin care are pretty different things. Although they may have shared origins and some benefits, one contains all the benefits of cannabinoids, while the other does not.

Still unsure about what is better for skin, hemp, or CBD? write us, we are always happy to help you out, and together we can make the right desicions.

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Exploring the CBD Edibles Market

Updated January 15, 2024
Written by
Avatar photo
Simon Šfiligoj
CBD Manufacturing
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

Overview of the CBD Edibles Market in 2021

Both the data and understanding of the CBD market are a bit sketchy. Some estimate that the CBD market in 2021 will be around 2.8 billion, while others estimate it at 3.5 billion USD. Again, it is because perfect data is unavailable, and thus many reports are based on expert estimates.

Things with CBD edibles are even more complex. It is simply because the definition of CBD edibles varies significantly from place to place. Most experts would consider CBD foods or chewable as CBD edibles. However, others may also consider CBD oil and capsules as edibles too.

However, it would be a good idea to keep CBD edibles separate from traditional oral CBD formulations like CBD oil or capsules. Thus, it would be right to say that CBD edibles include gummies, chocolates, brownies, honey, and other CBD food products. 

CBD Edibles Market Size & Growth

It would be difficult to say about the market size of an industry that is still poorly regulated and where many manufacturers do not share their sales data. Nonetheless, it would be correct to say that the market size of CBD edibles is at least 30% or more of the total CBD market. 

Thus, it may be correct to say that the CBD edibles market is at about 1 billion USD or even a bit more. Moreover, as per conservative estimates, it will continue to grow at the CAGR of 24.30% and is expected to reach or even cross the 5 billion mark by 2027. 

It appears that these estimates do not include CBD gummies. It is because CBD gummies alone have greater sales than perhaps all other CBD edibles combined. Thus, if CBD gummies are taken into consideration, it would be a much bigger segment. That is why some experts predict that CBD gummies are a big thing, and they alone may account for as much as 13 billion USD plus sales by 2028 and is growing at the CAGR of 30.7%.

It does not matter what figures we consider. It is evident that the market is bound to grow at a CAGR of 24 to 30%, which is quite a fantastic growth rate in comparison to other industries.

CBD Edibles Industry Trends

When it comes to CBD, gummies rule, they remain the most popular form of CBD products. In fact, gummies are generally becoming quite popular in the health supplements market. In some cases, they are even overtaking traditional preparations like oils, tinctures, and capsules. It could be because consuming gummies is comfortable, and it does not feel like taking medications, and they also come in many flavours.

Next comes the CBD infused food items like chocolates, brownies, and even other edibles. However, they have been slow to pick up due to multiple challenges. Because, generally, such edibles have a shorter product life, are bulkier, and involve logistics challenges. Further, they also have specific regulatory challenges. As the CBD market becomes more regulated, getting regulatory approval for CBD-infused food products may become challenging.

Another exciting segment to watch out for is CBD infused beverages. These are not indeed edibles, but some would include them in the segment. It is a niche segment, but its popularity is growing. It may grow considerably, as visible from the market growth of various other health drinks.

Another exciting trend to watch for is the acceptability of CBD by young and active adults. Lots of sales in CBD indeed come from adults aged 30 to 65 years, as they buy CBD for specific health benefits. However, a greater number of adults below the age of 30 are using CBD regularly. These are not individuals who are essentially living with some disease conditions. Instead, they buy CBD edibles to stay active, focused and energized. Many of these young adults may buy CBD edibles to overcome sports-related fatigue or to improve mood.

Essentia Pura’s Analysis of the CBD Edibles Market

Essentia Pura’s take on the CBD edibles market is that although this particular segment is bound to grow, it has some specific challenges. There is a good probability that sales of edibles may grow greater than other CBD types. This particular segment also has lower competition in comparison to CBD oils and caps. However, its diversification would depend on regulatory changes in the market. It may be challenging to get regulatory approval for products like CBD infused cookies or honey. In addition, CBD edibles’ legality remains an area of concern.

The safest bet at present is to expand in the gummies market. This is because CBD gummy bears are relatively easy to manufacture. They also have a dedicated and huge consumer base. Therefore, gummies do not pose much regulatory challenge. Moreover, studies show that 90% of the gummies market is of low CBD content gummies. Thus, 1 mg to 20 mg of CBD per gummy is what most consumers are looking for.

Although, it may be a good idea to experiment with some new offerings, too. Thus, one may increase brand value by introducing CBD chocolates, honey, candies, and similar other products.

Another point worth noticing is the changes in points of sales of CBD products. Although the shift from brick-and-mortar stores to online platforms is an old trend, covid-19 epidemics accelerated things. Even though in 2020, offline stores accounted for about half of all CBD sales. However, from 2021 and onwards, most of the sales would come from online sales and promotion.

CBD edibles in different regions

Finally, regarding the regions to focus on. Although data may show considerable and equal sales of CBD globally, most sales come from North America, UK, and the EU. Other regions Latin America, the Middle East, and South Asia are less likely to pick up any time soon. However, Asia Pacific is a region to keep an eye on, as it has a considerable middle-income population and tradition of using natural remedies.

One may produce CBD edibles using water soluble CBD for better bioavailability. Further, water soluble CBD just mixes quite well with various edibles. Else, one may consider buying CBD edibles wholesale and repacking them.

Opportunities for Businesses Expanding into CBD Edible Products

In CBD edibles market is dominated by CBD gummies. It is a segment that is also projected to grow considerably in the next five to ten years. Gummies are relatively easy to produce. Thus, those selling CBD oil may consider making gummies. Even new manufacturers may start their business with gummies. 

It is quite possible that gummies may overtake CBD oil, tinctures, and capsules sales in certain age groups and specific locations. Gummies are especially an attractive product offer for young adults, busy professionals. 

Additionally, one may consider certain niche segments like edibles for vegans or those on the keto diet. 

The good thing about CBD edibles is that consumers are not expecting a high concentration of CBD in these products. It is because they are not consuming these products to treat some medication conditions. Instead, they use CBD to stay healthy, focused, energized, and yet calm.

Which CBD edibles do you think the market is missing? Share your thoughts with us!

Looking for a reliable source of quality CBD ingredients? Reach out for a sample of our CBD isolates or distillates and add another layer to your recipes!

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Do CBD patches work?

Updated January 15, 2024
Written by
Avatar photo
Simon Šfiligoj
CBD Manufacturing
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

Everything you need to know about CBD patches

There are numerous methods of drug delivery, and the same is true for CBD products. Each delivery method has its pros and cons. A transdermal patch is a way of creating extended-release CBD products. Transdermal patch releases active ingredient slowly for hours, in some cases even in days.

In recent years, there has been increased interest in CBD patches, Hemp patches, Cannabis patches.

What are CBD patches?

Transdermal cannabinoid patches are non-invasive. It is a patch with adhesive applied to a specific part of the body. Once applied, CBD is slowly absorbed via the skin.

Many people find a CBD oil patch more comfortable than oral CBD oil. As, in this case, there is no need for multiple dosing during the day. One may simply apply the patch and forget about it.

Patches are slow to work but have a prolonged duration of action. They also help gain more predictable levels of the active ingredient in the blood as the patch slowly keeps releasing it. It means once an adequate amount of CBD has reached the blood, it will remain in that steady-state for hours. Thus, in specific chronic conditions, patches may be more effective.

Like other methods of delivery, not all patches are created equal. Some are made for a faster and short duration of action. Others are designed for prolonged activity. Some may use absorption enhancers to increase the efficacy of the product. 

How do CBD patches work?

Transdermal drug delivery is one of the oldest methods. Ancient practitioners have also utilized this method. Ancient people would often apply various herbal oils and pastes and cover them with leaves or cloth. However, modern medicine has been slow to pick up this route of drug delivery.

It has a very simple mechanism of action. When CBD patches are applied, CBD gets absorbed via the skin and enters the systemic circulation.

This route provides some distinct benefits like a steady-state of CBD in plasma, no first-pass metabolism, or degradation of CBD. No loss of CBD in the intestinal tract. Prolonged duration of action and improved patient compliance.

However, there are some variations in CBD absorption depending on age, ethnicity, skin hydration, gender, and so on. It means that manufacturers should test their products in various population groups before their commercial introduction.

There are already some early bioavailability studies showing that this route of administration works for CBD. Studies show that transdermal patches are slow to start acting. It may take few hours before any considerable amount of CBD could be detected in the blood. 

Bioavailability study shows that transdermal patch achieves steady plasma concentration after several hours. However, once this constant state is achieved, it is easier to maintain it than other dose forms. It means that patches are especially good for chronic painful conditions. Further, the bioavailability study shows that steady-state CBD concentration can be increased several folds by adding a permeability enhancer.

Transdermal CBD is preferred in many health conditions. CBD patches for pain relief are popular. CBD patches for anxiety are another area of interest.

Where do I put my CBD transdermal patch?

It is vital to understand that skin patches only work if applied correctly. For example, skin patches should not be applied to irritated or injured skin. In addition, one should not put a patch into the mouth or chew it.

When applying a patch, one should use certain precautions like not touching the adhesive side of the patch. Doing so may have an impact on how the patch works.

So, where do you place a transdermal patch?

Before starting, one should ensure that the skin is clean and dry. It could be especially important for those living in warmer climatic zones with lots of sweating. The best place to apply a patch is on the upper arm, chest, or even back. One should preferably apply a patch at places that do not move much.

Another essential thing to remember is that not to apply a patch on hair parts of the skin. It is because the patch would not stay in its place for long. Further, the presence of hair would also alter the rate of absorption.

If one needs to clean a part of the skin before applying a patch, it is better to use plain water. Likewise, one should avoid using oils or even alcohol-based cleansers.

After applying the patch, press it firmly for about 30 seconds to ensure it stays in place.

How long any patch can be applied would differ, as the technologies used to produce patches vary significantly. For example, some patches are made to be applied once every day. However, certain technologies might allow 72 hours of action.

Manufacturing CBD patches

The manufacturing approach would differ, as there are numerous proprietary technologies available.  Each technology has its pros and cons. Some may provide better adhesive properties, while others may have higher bioavailability and prolonged duration of action. Therefore, a CBD transdermal patch manufacturer would need to explore some technologies.

Most patches would have these five components:

  1. Protective liner: It is removed before the application of a patch. Its role is to protect the patch when it is stored. It may also help enhance the stability and shelf-life of the product.
  2. Drug reservoir: It is precisely where the active ingredient, that is, CBD, is contained. There could be certain technologies to ensure that a definite amount of CBD can be applied to any patch.
  3. Drug release membrane: It is generally regarded as the most vital component of any transdermal drug delivery patch. This membrane comes directly in contact with the skin, and the rate of drug release or CBD release is highly dependent on this membrane. Therefore, this membrane must be compatible with CBD.
  4. Contact adhesive: It ensures that the patch sticks to the skin. Again, there are numerous medical-grade adhesives available with various degrees of sticking strength. Strong adhesive is not necessarily better as the patch must be removed, too. The adhesive ought to be hypoallergic to avoid local skin reactions.
  5. Clear backing: It protects a patch from outside contamination.

To conclude, transdermal drug delivery is not new, and neither is its use in medicine. Transdermal patches were first approved by US FDA and European nations in the late 1970s. It means that there is a lot of experience in using patches for drug delivery. There are numerous drugs available in this form. CBD patch manufacturers need to build upon this extensive experience of the pharma industry with patches.

What is your opinion on the CBD transdermal patches? Share your thoughts with us at info@essentiapura.com

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Exploring the Water Soluble CBD Market

Updated January 15, 2024
Written by
Avatar photo
Simon Šfiligoj
CBD Manufacturing
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

Introducing Water Soluble CBD

Days of offering clients just a CBD oil are over. There is intense competition in the market. Thus, a successful CBD company must offer its clients value-added products. It is also vital to provide a wide range of products.

Differentiating the product from others is the key to success. And offering products with better bioavailability in a greater range may help. For example, water soluble CBD may offer an edge over competitors, helping enhance the range of products.

The Water Soluble CBD Market

The water soluble CBD market is relatively nascent yet. It means that it is the right time to explore this segment. Almost every day, there is news for one or another manufacturing launching its water soluble series in the market.

At present, most launches of water soluble CBD are happening in larger markets like the UK or Germany. However, it is worth understanding that many EU markets like France or Nordic regions will grow quite fast in the near future. As a result, the European CBD market is expected to grow by at least 400% in coming four years.

Water Soluble CBD’s use in the Food industry

Almost all food items require adding water, and only some foods have added oils. It means that water soluble CBD offers innumerable opportunities. Theoretically, it can be added to any food item without any changes to the original recipe.

Did you know that cannabis edibles have been consumed for thousands of years? In India, marijuana-infused sweets and beverages are offered to lord shiva. It is a tradition people have been practicing since the Vedic era, that is, for the last few thousand years. Offering cannabis edibles is a part of rituals. That is why marijuana-based products (full-spectrum CBD with high THC) were never banned in the holy city of Varanasi.

Here are some of the most common water-soluble CBD food items available these days:

Baked goods

Some manufacturers are already producing CBD-infused cookies in small batches. However, due to issues related to shelf-life and specific regulatory challenges, CBD-based baked products are generally made in small quantities for local sales. Therefore, producing a range of CBD-baked products may be a good idea for smaller manufacturers.

Chocolate

Europeans are the largest per capita consumers of chocolates. As chocolate has a good shelf life, there are already many manufactures into it. The good thing is that, quite like regular chocolate, people can use CBD chocolate to make their favorite recipes like brownies, chocolate-dipped cones, and much more.

Gummies & candies

Gummies and candies are among the most common and preferred ways of consuming CBD. They can be produced in innumerable flavors and types. Of course, one may use regular CBD isolate powder or CBD crystals to make them. However, water soluble CBD isolate would provide much higher bioavailability.

Snacks foods

It is another less explored area by manufacturers. Sportspeople love CBD. One may produce CBD-infused energy bars, high CBD hemp protein bars. These are examples of excellent value-added products, as they provide CBD along with other health benefits. One may position their product as something that helps with quicker recovery post-workout, and so on.

Cooking ingredients

On searching the internet, one may readily understand how underexplored this segment is. For those selling CBD products via retail chains, supermarkets, cooking ingredients could be an excellent idea. One may add CBD to various blends of spices, baking powders, and much more.

Condiments

CBD-infused sauces are already making their way to the shelves of certain retail chains.

Water Soluble CBD’s use in the Beverage industry

This is where water soluble CBD excels. After all, one cannot create water-based drinks using CBD oil.

The market trend is usually to create sparkling CBD water/drinks. There could be three options for most manufacturers:

CBD infused energy drinks

It is no secret that CBD is mainly loved for its ability to help fight pain and its calming effect. Such drinks may be targeted towards those living an active lifestyle, though not necessarily. One may even create a pre or post-workout drink.

CBD infused soothing drinks

Many people love the calming effect of CBD. Thus, it is a common idea to create CBD drinks infused with extracts of other calming herbs like chamomile, lavender, ashwagandha. These drinks could be good for countering mild episodes of fear and anxiety. They may also help sleep better.

CBD infused flavored or refreshing drinks 

It is the most straightforward approach of adding CBD to commonly used various flavored or refreshing drinks. Such drinks are usually for frequent consumption, and thus only small amounts of CBD need to be added to them.

Water Soluble CBD’s use in the Cosmetic industry

Infusing CBD to cosmetic products helps create cosmeceuticals, products that not only enhance beauty but have some health benefits, too.

Topical use of CBD is supported by science, as there is evidence of endocannabinoid system (ECS) in the skin. Dysregulation of ECS may have a role in eczema, psoriasis, and even skin cancer.

CBD topical products may offer some unique benefits. CBD may help enhance the hydrating, moisturizing, anti-inflammatory effect of some products. In addition, CBD may help reduce skin itching, slow down skin aging, and much more. 

Although CBD oil may be used to produce CBD cosmetics, water-soluble may help create non-sticky unique skincare products. Following products good could be a good option to enter the CBD cosmetics market:

Skincare serum

Serum for special skin concerns like acne. CBD may help due to its mild antimicrobial activity and anti-inflammatory action.

Powders

These are generally for preventing skin itching, especially during summer. Such a powder may also help prevent skin allergies caused by certain fabrics.

Makeup cleansers

Makeup cleanser with anti-inflammatory action may be quite an attractive product.

Moisturizers

Moisturizing creams are one of the most commonly used products. However, adding water soluble CBD may have some additional benefits in such products.

Sunburns soothing cream

CBD may help reduce skin inflammation and irritation caused by sunburns. 

Massage gel 

Oil-based massage creams or massage oils are indeed loved by many, but not all. Some individuals do not like oily skin left after the massage. Water soluble CBD-based oil-free massage gel may be a great option for many.

Lip balm

Water soluble CBD may be especially effective in preventing local irritation, cracking of lips.

Evening skincare gel

Many people like to apply skincare gels in the evening. When skincare products are applied to the skin before going to bed, they have ample time to work.

Shampoo

CBD shampoos are often recommended for preventing hair loss. In addition, CBD may help due to its antimicrobial, antifungal, anti-inflammatory action.

To conclude, the above are just some of the unique ways to enter a highly competitive CBD market. One may procure water soluble CBD isolate or full spectrum water soluble CBD wholesale and start producing some of these products.

Cosmetics, food, or beverages? Let us know where you think water soluble CBD shines the most. And to make your water soluble formulations happen, contact us on this page.

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5 minute read

How To Make Water Soluble CBD?

Updated January 15, 2024
Written by
Avatar photo
Simon Šfiligoj
CBD Manufacturing
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

CBD oil is the most commonly used form of cannabidiol. Although it has moderate bioavailability of 13-19%, that is not enough. Moreover, when people take CBD oil, lots of it goes through first-pass metabolism (metabolism in the liver immediately after absorption), and a considerable amount of it is destroyed.

These issues related to CBD bioavailability forced researchers to look for alternative ways of delivering CBD to the body. Of course, CBD inhaling is an excellent option, however it is not for everyone. Thus, researchers came up with another technology that is creating water soluble CBD.

What Is Water Soluble CBD

A substance can be described as water soluble essentially when it has the capability to dissolve in water. CBD does not have this ability naturally so we have to process it in order to be able to disperse it in water and other liquids. The finished product that can easily be added to food or drink, which provides endless opportunities for different types of products. But this process can be quite complicated.

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Challenges in creating water soluble CBD

It is not as straightforward as it may sound. One cannot just directly dissolve CBD isolate or CBD distillate into the water. It is because the CBD molecule is lipophilic. That is, it loves oils but repels water. So, only an inconsiderable amount of CBD powder would dissolve in the water.

Nevertheless, researchers have long known various natural products in which oil molecules are suspended in water as if they are mixed with it. It is called emulsion. Some of the good examples could be milk and egg yolk. There are known ways of emulsification, and the same can be applied for producing water soluble CBD.

The word liposome derives from two Greek words: lipo (“fat”) and soma (“body”)

How water soluble CBD is made

Water soluble CBD isolate or distillate still require the use of oil. It is because CBD simply does not mix well with water. So, how to make water soluble CBD? The starting point in creating water soluble CBD is mixing it with oil. Then comes the next step, which is breaking these CBD oil particles into tiny (nano) droplets so that they can remain suspended in the water. Thus, the resulting solution is a nano-emulsion.

There are many ways of breaking CBD oil into smaller particles. But the most common strategy used is deploying either high shear mixers or high energy ultrasonic sound waves. There are special machines in which this whole process is carried out. This equipment can break CBD oil into nanoparticles, small enough to get homogeneously suspended in the water, and remain stable for quite a long time.

Usually, ultrasound homogenizers (using ultrasonic waves) are regarded better than high shear mixers (moving oil and water mixture at high velocity). However, most producers use a combination of these methods. One can start with high shear mixers and then use ultrasound homogenizers to produce even better and more stable nano-emulsion. 

These nanoparticles are so small that they can readily penetrate through various membranes, including intestinal membranes. These particles can also escape the first-pass metabolism in the liver in large amounts. All this means far greater bioavailability of CBD.

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Liposomal CBD vs water soluble nano-emulsion

There are other well-known ways of boosting the bioavailability of various natural extracts. One such method is using liposomes as carriers. Liposomes form a bubble-like structure over natural extracts like CBD resulting in better absorption.

Although there is no doubt that liposomal CBD has better bioavailability than CBD oil, it is still inferior to water soluble nano-emulsion. It is because the size of CBD droplets in nano-emulsion is extremely small. In contrast, liposomes are 10 to a hundred times larger than nano-emulsion droplets. Thus, despite the benefits of improved bioavailability, liposomal technology is much inferior to water soluble nano-emulsion.

Both offer bigger efficiency. but nano, being smaller, is also absorbed better!

Kinds of water soluble CBD

When choosing water soluble CBD, one does not have to compromise on the range of options. Like non-water soluble options, water soluble CBD is available as isolate, distillate, and even full-spectrum.

Water soluble CBD isolate 

Much like CBD isolate powder or CBD crystals, it contains CBD without other cannabinoids and is THC-free. It is loved by many due to its perceived better safety profile and a wide number of applications. It may be a better fit for certain kinds of products like edibles, CBD for older adults and athletes, and so on. Nonetheless, it is less potent due to the lack of entourage effect.

Water soluble CBD distillate

This is perhaps an optimal solution for most needs. It contains CBD, other cannabinoids, and terpenes but is free from THC. Thus, it is generally regarded as quite potent and safe for special population groups who do not want any THC like athletes.

Full-spectrum water soluble CBD 

As the name suggests, this is CBD along with other cannabinoids, terpenes, and even traces of THC. THC is only in the permissible levels, which is usually below 0.2%. Therefore, it is a very small amount of THC to cause any mind-altering effect. However, full-spectrum water soluble CBD wholesale might be better for producing products for severe conditions like anxiety, sleep disorders, and so on.

Various pharmaceutical drugs, mRNA, and DNA vaccines are using liposomal delivery methods.

6 Water Soluble CBD Benefits

There are numerous benefits of water soluble CBD:

  1. The main and most noticeable benefit is that water soluble CBD provides a very high absorption rate. This means that a certain dose will show more powerful effects than with other forms. Many of its other benefits correlate with this greatly.
  2. It is a cost-effective way of enhancing the bioavailability of CBD, which helps keep the cost of CBD products low and yet improve its effectiveness.
  3. Water soluble CBD is proven in human studies to have reliably better pharmacokinetics. In one of the human studies, water soluble CBD was 4.5 times more bioavailable than CBD oil. Thus, it is considerably better than other technologies like liposomal or the addition of other herbal extracts.
  4. Convenience for both users and producers. For users, water-soluble products are easier to use and carry. For producers, it also means ease of adding CBD to various formulations.
  5. It starts acting faster, and thus, those who use water soluble CBD always prefer it.
  6. Another benefit of water soluble CBD is that it can be more easily measured and dosed due to the precise nature of the process it goes through.

It is vital to understand that not all benefits of it are visible. For example, water soluble CBD achieves a much higher concentration in various organs, especially when used for prolonged intervals. It means that people may achieve health effects that they could not get from other types of CBD products.

Would you like to see a different approach in making CBD water soluble? We are open for discussions at info@essentiapura.com. If you are ready to dive into water-soluble CBD, complete our contact form here to get your samples!

 

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What is Water Soluble CBD?

Updated January 15, 2024
Written by
Avatar photo
Simon Šfiligoj
CBD Manufacturing
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

When it comes to CBD products, things are evolving fast. It isn’t easy to believe that CBD primarily became legal just a couple of decades back. However, since then, lots have changed. Consumers are now more quality conscious and informed.

The CBD market has long been dominated by CBD oil, but things are changing fast. CBD oil has its own pros and cons. It is vital to understand that the human body is mainly composed of water. Thus, it handles water-soluble compounds better. 

It is not rare for CBD manufacturers to see their consumers complaining about their products. It is because some products fail to deliver despite the best of intentions of CBD producers. Researchers think that one of the reasons could be that many oil-based products do not get absorbed much into the body. So, could a solution be in the form of water soluble CBD?

Exploring Water Soluble CBD

Water soluble CBD empowers manufacturers to create a whole range of new kinds of products. More effective products, and yet easy to produce. 

What is Water Soluble CBD?

To begin with, one should not confuse CBD with CBD oil. It is true that CBD is highly lipophilic and mixes much better in oil than in water. However, it does not mean that CBD does not dissolve at all in the water. Nevertheless, technological challenges remain, as low water solubility must be overcome.

Various researchers are investigating different approaches. Some are even exploring ways of tweaking the chemical structure of cannabinoids to make them more water soluble. But perhaps the more straightforward approach is to create CBD emulsion.

It is wrong to suggest that water and oil do not mix, as they do mix well even in nature. Just take an example of milk, a classic example of an emulsion. It is a water-based food product with suspended fat particles. 

Milk – A prime example of fat nanoemulsion

When creating water soluble CBD, manufacturers use a similar approach to creating CBD emulsions. Thus, it is a nano-particle of CBD oil dispersed in water, creating an emulsion. This emulsion could be made from isolate (containing primarily CBD only), resulting in water soluble CBD isolate. Or it could be broad-spectrum (thus containing other cannabinoids, terpenes, for added benefits), resulting in water-soluble CBD distillate.

Water soluble CBD – a better delivery system, higher bioavailability

The whole purpose of creating this type of CBD is to enhance CBD’s delivery. It means increasing its bioavailability considerably and thus improving the safety and efficacy of the product. 

Higher bioavailability means that CBD would be effective even at lower dosages, which considerably improves its safety. In addition, a higher concentration of CBD in the body would mean better relief from various health issues.

Although there are very few studies on the subject, all studies confirm that water soluble CBD is multiple times better. 

In one of the pharmacokinetics studies published in the Phytotherapy Research journal, researchers found that water soluble CBD had 4.5 times higher bioavailability than lipid-soluble CBD (CBD oil) on oral intake. So, the difference is enormous.

Water soluble in liquid or in powder form? Find out in the next article!

Benefits of Water Soluble CBD

There are several reasons for consumers to prefer water soluble CBD:

  • Higher bioavailability means greater effectiveness even at lower dosages.
  • Higher concentration in the blood means that water soluble CBD may help in conditions where CBD oil failed to help.
  • Easier to add to food products, but more importantly to various drinks and beverages.
  • Easier to carry than CBD oil

Above are the benefits from a consumer point of view. Water soluble CBD also offers numerous advantages for CBD manufacturers:

  • Can be added to various beverages without altering their formula or recipe.
  • Ability to produce a greater variety of CBD products.
  • Higher and predictable health benefits for consumers means greater client loyalty and higher brand value.

Types of Products made with Water Soluble CBD 

One can use water soluble CBD isolate or broad-spectrum distillate to produce just almost any kind of CBD product. Quite like CBD oil, it can be added to various food items, gummies, and so on. However, the most significant benefit of water soluble CBD is that it can be readily added to a wide variety of drinks or beverages like cold brew coffee, flavoured drinks, cold tea, etc.

Since it is almost tasteless and readily mixes into water based beverages, in most cases, manufacturers won’t require to make changes to their pre-existing recipes. All they need to do is simply add it to any of the well known beverages.

The Difference between Water Soluble CBD and CBD Oil

The main difference between the two is in faster, greater, and reliable absorption when taken orally. It ultimately translates into quicker relief, higher efficacy, and consistent health benefit.

This is not to suggest that CBD oil is not as good. Nevertheless, water soluble formulations are better in most ways.

The world of CBD beverages is now possible with water soluble CBD.

Manufacturing products with water soluble CBD

There are some differences from a manufacturing point of view. It is vital to understand that water soluble CBD isolate and distillate are in liquid forms, unlike CBD isolate or broad-spectrum distillate powders. Thus, they might be better suited for adding to beverages, other water-based products. However, water soluble CBD isolate or distillate may not be suitable for adding to certain topical products. 

One of the common questions manufacturers ask is why not use cheaper CBD isolate powders to create beverages? Or Is CBD isolate water soluble? Unfortunately, the usual CBD isolate powder is only marginally soluble in the water. Thus, it will not achieve a high concentration. Therefore, adding too much of it to beverages will result in sedimentation. On the other hand, water soluble CBD isolate or distillate (both are in liquid or emulsion form) would readily mix, providing the correct dose to the users.

Is water soluble CBD the future? Find it out your self and order some samples using our contact form. Whether you require more information on the matter send us an e-mail!

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Can You Vape CBD?

Updated January 15, 2024
Written by
Avatar photo
Simon Šfiligoj
CBD Manufacturing
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

Answering Common Questions on Vaping CBD

In this article, we feature Michael from Got Vape with an introduction to vaping CBD!

Vaping and CBD are more popular than ever. But, can you vape CBD? It is certainly possible! We will get into the different types of CBD and how you can vape them.

Can you Vape CBD?

Manufacturers have been finding more ways to vape CBD. The use of oil vape pens is a misnomer. While they talk about CBD vape oil, there is no actual oil used. Vaping is accomplished with the use of CBD e-liquid, or e juice, or vape juice. This includes combinations of propylene glycol and vegetable glycerin, with CBD extract.

Most commonly, CBD vape oil actually includes isolates suspended in a liquid that is safe for inhaling. This can also be called an infusion. In addition to infusing isolates, there are full-spectrum and broad-spectrum products available. Isolates are strictly CBD with no trace of THC.

Broad-spectrum and full-spectrum CBD products will use more of the plant’s active ingredients. These products will contain trace amounts of THC (never more than 0.3%). People using broad-spectrum and full-spectrum CBD products are after the entourage effect. This is where the different compounds, other than CBD, work together to increase the effects each offer.

Make sure not to confuse CBD vape oil with hemp seed oil. The MCT (derived from coconut) oil and hemp seed oil are damaging to your lungs. According to the NCBI, it could lead to conditions such as lipoid pneumonia.

CBD e-juices for electronic cigarettes come in various flavour which make CBD vaping even more exciting!

What Does Vaping CBD Feel Like?

Using a CBD vape is an effective way to get CBD into your system quickly. By inhaling it, the CBD will enter your bloodstream through the lungs. Typically, by using a vape, you will feel the effects of CBD within minutes.

CBD has been used by many to counter pain and inflammation. It is important to realise that most of the claims of health benefits from CBD are not fully proven by studies.

Effects from vaping CBD may vary from one product to another. Generally, you may feel energised at lower doses, while higher doses may make you feel relaxed.

Consuming oil as a part of a tincture, or added to food, has to first pass through the digestive system. This slow absorption process tends to increase the time in which it will take effect. It may take up to two hours to feel the effects when consuming CBD this way.

Another difference between vaping and consuming CBD is the duration and intensity. Vaping may have a shorter duration, but a more intense effect. This is because when consuming CBD, it passes through the liver. This partial metabolises CBD before it enters your bloodstream.

What Types of CBD Can You Vape?

When you are ready to get started with a CBD vape, you need to know what you can and cannot vape. Let’s take a look at the different formats CBD can be available in. We will discuss which ones are good for vaping, which will damage your lungs, and which will damage your vape device.

CBD Liquid

This is the most popular form of CBD for vaping. You can use CBD vape oil that is in different formats like broad-spectrum, full-spectrum, or isolates. They are easy to use with either cartridges or tanks available. This is the least damaging vaping format.

CBD Crystals

This is a CBD isolate that is generally in a powder format. It is not intended to be used for vaping. Attempting to do so may cause harm to your vape device. Some have mixed the powder with an oil carrier, but this is not recommended for vaping. CBD crystals are very potent and are best diluted in PG and VG!

CBD Juices

Similar to liquid, this CBD vape product allows you to have different flavours.

They are available in different concentration levels as well as different types. Many like to use the broad and full-spectrum due to CBD crystals.

CBD Crumble

Using crumble is not legal in the UK and EU. This is a concentrated format for CBD. It requires a special vaping device and could cause damage to a standard vaping device meant for use with CBD vape oils.

CBD Flower

The concentration of CBD will be lower in flowers, but it is also the most flavourful. You will need a vaporiser in order to use flowers. Flower CBD concentrations will differ, and there will always be trace amounts of THC. This is the least damaging format for your lungs.

How Much CBD Should You Vape?

As with any vaping, it is best to proceed with caution. Dosing recommendations always err on the side of a lower dosage. For this reason, you should start with somewhere around 10mg per day. Increase your dosage until you find the perfect level for you.

CBD Electronic cigarettes are a healthier alternative to traditional cigarettes and can help abandon the habit of smoking.

Regulate your usage based on how much vaping you do throughout the day. It is suggested that vaping, in general, is not entirely safe. Protect yourself by only purchasing vape oil from a manufacturer with a commitment to quality. Look for those with laboratory testing for purity and potency.

Are CBD vape oils types of Nutricosmetic/Nutraceutical products?

Many who are interested in CBD may also be interested in nutricosmetic supplements. These are products consumed orally. They contain specific nutrients and antioxidants. The intended use is to help with skin, hair, and overall care. The different products available are based on consumer demand. This can include:

Capsules

These are easy to swallow and deliver specific quantities of nutrients in a time-released format. These are convenient to carry with you at all times and take as needed.

Powder

This allows you to make a drink while you are on the go that can be consumed over time. These can be sold in bulk or premeasured and packaged sachets. Most will have no flavour, but you can find flavoured powders.

Tinctures

Premixed liquids make it easy for you to drink down the nutrients in a concentrated format. Adding in flavours to the tinctures makes them more palatable and easier to consume than a pill.

Gummy candy – Just like with CBD, gummy candies make getting your health boost more enjoyable. Different flavours offer you more variety in getting your boost.

Chewing Gum

This relies on the capillaries in the mouth to deliver the nutrients and antioxidants into the system. Again, different varieties in flavours help to make this more enjoyable.

The beauty from the inside-out mindset is exactly what nutricosmetic supplements are all about. It goes hand in hand with eating organic fruits and vegetables and responsibly sourced ingredients for your diet.

More research is still needed in order to find the efficacy of nutricosmetic supplements. Products on the market should be tested and certified by independent laboratories. Make sure to purchase from reputable manufacturers when entering this market.

While CBD vape oils are also a recent invention, they aren’t intended as nutritional supplements and are targeted towards recreational markets.

For more information, read our piece: What are Nutricosmetics?

 Conclusion

As you can see, CBD vape oil effects will depend on many factors. How you vape as well as what you vape is up to you. You should take some time to sample different methods to determine which ones are right for you. You may find some products that are perfect for different occasions, so you can plan accordingly. Happy vaping!

Let us know if you have any questions about CBD vaping or CBD liquids. Are you interested in manufacturing any of these products? We would love to talk with you about your interest!

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What are Endocannabinoids

Updated January 15, 2024
Written by
Avatar photo
Simon Šfiligoj
CBD Manufacturing
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

The Endocannabinoid System Explained

The Endocannabinoid system (ECS) is one of the human body’s biological systems discovered fairly recently, in 1990. Like the pulmonary system, circulatory, skeletal, muscular, and skeletal systems all have their specific functions, so does the Endocannabinoid system. 

The ECS is responsible for regulating the activity of all the other biological systems which ensures their proper functioning. This means our ECS affects everything the human body does and is affecting us every second. How come we know so little about such an important part of our lives?

A brief history of the Endocannabinoid system

As scientists were trying to figure out how cannabis works, mainly how Tetrahydrocannabinol influences us, they found the receptors to which THC can bind if consumed. Hence naming them cannabinoid receptors. To their surprise, they found the cannabinoid receptors scattered all over the human body. 

And even more stunning, they discovered an endogenous ligand, for which the cannabinoid receptors exist. Later, they found more chemicals produced by our bodies that interact with cannabinoid receptors and named them endocannabinoids.

The first identified endocannabinoid, anandamide, was documented in 1992. The researchers were amazed how anandamide structurally resembles THC, and how similar it is in activity when it binds to receptors. Soon, they uncovered another compound, 2-AG, mostly located in our brain which has a great affinity to cannabinoid receptors. Later, more followed.

A well-balanced diet is key for a healthy endocannabinoid system. Essential amino acids, fatty acids, vitamins, and minerals are all very important for the biosynthesis of endocannabinoids!

What are Endocannabinoids?

These fascinating compounds are produced in our bodies and act as signaling molecules, similar to neurotransmitters. Like neurotransmitters, they are produced in the neuron cells and their role is to send messages from one neuron to another. However, endocannabinoids are produced in the postsynaptic neuron, contrary to neurotransmitters which are produced in the presynaptic neuron. 

By going in the opposite direction in neurons the endocannabinoids bind to cannabinoid receptors regulating the amount of neurotransmitter release in the presynaptic neuron.

With this counter grade signaling, endocannabinoids like Anandamide and 2-AG serve as a blocking-releasing mechanism. Their role is to limit neurotransmitter activity by tapering their release. Doing so they are slowing down the neurotransmitter-receptor interaction which prevents the nervous system from getting burned out. 

Neurotransmitters like dopamine are produced in the Presynaptic Neuron and travel to the Postsynaptic Neuron. The endocannabinoids are the opposite!

The Role of the Human Endocannabinoid System

Endocannabinoids, cannabinoid receptors, and enzymes are in charge of taking care that every function in our body works properly. The Endocannabinoids are biosynthesized on demand through enzymatic production in the postsynaptic neuron.

In case neurotransmitters are required to send signals, the endocannabinoids are not produced. If the neurotransmitters are too active, endocannabinoids are made and sent into the presynaptic neuron to limit neurotransmitter activity.

For now we are aware of these endocannabinoids which influence our CB1 and CB2 receptors: Arachidonoylethanolamine (Anandamide or AEA), 2-Arachidonoylglycerol (2-AG), 2-Arachidonyl glyceryl ether (noladin ether), N-Arachidonoyl dopamine (NADA), Virodhamine (OAE), Lysophosphatidylinositol (LPI)

Examples of how endocannabinoids system regulates our bodies:

  • If we get in danger, our body starts to send adrenaline through our neurons. Dopamine signals our body to breath faster, the heart rate rises, we become more alert and focused. Once out of danger, we do not require dopamine anymore. Endocannabinoids are deployed and stop dopamine from being released. We are calmed down.
  • When it gets dark at night, our body starts to send melatonin through our neurons. Melatonin signals our body to slow down and rest, we become tired and sleepy. In the morning, endocannabinoids send messages to melatonin to stop releasing. We become awake and it’s time to get up!

After the situation settles, endocannabinoids are not required anymore and get degraded by enzymes. Enzymes like FAAH (Fatty acid amide hydrolase) and MAGL (Monoacylglycerol) also make part of the endocannabinoid system, along with CB1 and CB2 receptors and the endocannabinoids. The enzymes are a very important part of our ECS since they make the breakdown of endocannabinoids possible, which basically means the enzymes shut down the endocannabinoid activity.

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Our endocannabinoid can benefit greatly with cannabidiol intake Hemp extracts show great potential in treating all kinds of problems because of its positive impact on our ECS.

The Endocannabinoid System and CBD Oil

As we found out, the endocannabinoid system has a very big influence on our life. What happens if the system does not work as it should? 

The consequences of a distorted endocannabinoid system are seen in:

  • Unexplained mood swings and sudden changes behavior
  • Irregular sleep patterns and eating disorders
  • Migraines and other forms of headaches
  • Autoimmune diseases and Nervous system diseases

The reason for the malfunction of an endocannabinoid system can be neither:

  • Cannabinoid receptors can get worn out due to stress, lack of sleep, etc.. and are unable to receive endocannabinoid signaling
  • Enzymes are not working correctly, (likely because of unhealthy diet or alcohol and drug abuse, poisoning) and too many endocannabinoid are present which result in a hyperactive endocannabinoid tone
  • Endocannabinoid deficiency, meaning the body does not produce enough of its own cannabinoids to support other processes.

And for all the reasons above, CBD oil comes into play. CBD can solve many issues by simply putting our endocannabinoid system in check. Cannabidiol can influence all 3 parts of our ECS:

  • it binds to CB1 and CB2 receptor without activating them, which puts them to rest
  • CBD supports the body to produce more endocannabinoids
  • Cannabidiol diminishes enzymatic degradation of endocannabinoids, increasing their count

Conclusion

In the perfect scenario, we would not need CBD to supplement our endocannabinoid system. With a healthy diet, daily exercise, unpolluted air, and water, a consistent sleep regimen,… the production of our own cannabinoids would be sufficient.

Meditation, yoga and other exercises, social activities like dancing and singing all pronounce our endocannabinoid tone!

However, the modern lifestyle which we live today shows quite the opposite. Lots of processed food, long work hours, stress on every corner, all take a toll on our endocannabinoid system. With little time to care for ourselves, CBD offers the ultimate solution to boost our ECS to make our minds and body happy.

Essentia Pura is one of the leading CBD manufacturers in Europe and can supply CBD in various forms for every situation. From full-spectrum CBD oil to CBD isolate, we bring to the market CBD products for all kinds of consumers.

Therefore, if you feel the urge to make the world become a better place, you can do so with CBD. Get in touch with us to discover all the Essentia Pura CBD options and help to make a healthy endocannabinoid system available for everyone!

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Cannabigerol (CBG) Overview, Uses & Benefits

Updated January 15, 2024
Written by
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Simon Šfiligoj
CBD Manufacturing
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

Cannabigerol, CBG in short, is another cannabinoid that is well represented in the plant Cannabis Sativa. There are more than a hundred cannabinoids found in the cannabis plant, most of which are still unidentified. We know a whole lot about tetrahydrocannabinol (THC) and are becoming very fond of cannabidiol (CBD). But there are a handful of minor cannabinoids which are about to bust the door open into the market.

The first in the line is CBG! CBG is already being sold in the same forms as we can find CBD. CBG drops, CBG sprays, CBG gummies, CBG softgels, CBG mints, CBG skin care, CBG flowers.. It is either found alone or incorporated into CBD formulations in different ratios. What makes CBG different from CBD is a matter of scientific debate. Still, many users already report very positive results with their newfound cannabinoid. 

In this topic, we will explore how CBG is made and what the researchers think of it. We will explore which products are the best for CBG applications, what are the CBG benefits, how it stands on the market, and what the future holds for CBG.

What is Cannabigerol (CBG)?

It is quite interesting that CBG started to gain traction just recently, as the cannabis plant actually produces larger quantities of CBG than CBD or THC. It is really important to know how this magic happens! 

From Cannabigerolic acid, many cannabinoids like CBD, THC, CBC,.. are born.

Where does CBG come from?

Most cannabinoids are biosynthesized by the cannabis plant during its flowering stage. When the buds and trichomes start forming, the chemicals olivetolic acid and geranyl diphosphate react together. The result of synthase is cannabigerol acid, CBG in its acid form. Out of cannabigerol acid (CBGa), several cannabinoids are formed from CBGa. reacting with different catalytic enzymes. 

This is also how CBD and THC are formed. Cannabis is always harvested at full maturity, either to produce ripe seeds for oil production or ripe flowers for CBD extraction. Hence, little CBG is present in cannabis at harvest as most CBG was transformed into CBD and other cannabinoids through molecular reaction changes.

Is CBG legal?

Especially in industrial cannabis varieties, suited for legal cultivation, we can find high levels of CBG even at harvest. This was achieved by selective breeding of cannabis varieties in which the enzyme responsible for catalyzing the formation of THCA from cannabigerolic acid (CBGA) is almost absent. 

The result is a cannabis variety with all the traits needed for commercial cultivation but without detectable levels of THC. The breeding to make low THC cannabis available for legal cultivation is what actually brought CBG cannabis varieties to life. 

Otherwise, the CBG compound is 100% legal all across the world since it does not fall into internationally controlled narcotic drugs under the 1961 Convention. There are no registered pharmaceutical drugs that contain cannabigerol, which could pose any other restriction on sales and consumption of the CBG compound.

Just recently, Panakeia was developed. The first cannabis variety that is completely free of THC and rich in CBG!

How is CBG made?

These varieties also made the production of CBG possible on a larger scale!  After harvesting CBG rich hemp biomass, we dry and cure the plants. To prepare them for extraction we finely mill the plant material. We then transport the ground CBG biomass to our lab facility where we process it using supercritical CO2. We obtain oil that is rich in cannabigerol acid. From here it is a pretty straightforward process to obtain CBG from CBGa via decarboxylation.

How CBG Affects the Human Body

Now we know that CBG is the parent molecule of the cannabinoid family, but how does this mother cannabinoid affect the human body? CBG affects cannabinoid receptors in the human body similar to CBD.

CBG antagonizes the CB1 receptor, meaning it has a blocking effect on the receptor which causes the “high” effect if activated. This makes CBG nonintoxicating. Similar to CBD, the binding on CB1 receptors with no action, produces 0 negative side effects. 

On the other hand, by binding and blocking CB1 receptors, we see a positive change in our bodies. As CB1 receptors are spread throughout our system, if they are blocked, they are calmed. This produces a “rest & relaxed” feeling as opposed to “fight or flight” feeling if CB1 receptors are stimulated.

When we are in the “Rest & relaxed” mode, or better in the parasympathetic state, we enable our body to calm, heal and regenerate.

On the second human cannabinoid receptor CB2, CBG has a more significant effect. Since it is a partial agonist on the CB2 receptor is has a clear action. Compared to CB1 receptors, which are located mainly in our central nervous system, we find CB2 receptors all around from hair to toes.

CBG flower resembles the traditional one very well. Usually, the flower appears whiter in color! As the plant stops developing further from Cannabigerolic acid, the trichomes never ripe.

Side effects of CBG

Patients that are using CBG to treat various issues report little negative side effects from its use. In a research survey many recommend it as a better and more effective option when compared to traditional medicine as the latter often presents with more unpleasant and long-term side effects or even addiction.

The main complaints from patients using CBG were dry mouth, sleepiness, hunger, and dry eyes. It is also important to note that just over half of the patients reported any of these side effects and others noticed none at all. The withdrawal symptoms were even less noticeable, with only about 15% reporting any. The most common symptom amongst those who endured any withdrawal was difficulty sleeping.

Although much more research needs to be carried out to conclude anything with certainty, these early results are very promising, showing minimal side effects and negligible withdrawal symptoms.

7 science-backed CBG Benefits 

So far, science has proven many beneficial effects of CBG on the human body. The list begins more general and then moves into more specific ones.

  1. By turning off and easing CB1 receptors, conditions that affect the central nervous system can be alleviated
  2. By acting on the CB2 receptors, conditions affecting organs can be alleviated
  3. Antibacterial effect: CBG was found to be effective against Gram-negative organisms like MRSA, by inhibiting the inner membrane of the pathogens
  4. Appetite stimulation: Cannabis was always an effective treatment for chemotherapy patients who suffered from loss of appetite. The effect was mostly attributed to THC. Now non-psychoactive CBG has been proven to have a massive appetite stimulative effect!
  5. Anti Inflammatory: CBG shows strong anti-inflammatory effects for patients who suffer inflammatory bowel disease like Chron’s disease. It can also alleviate neuroinflammation in multiple sclerosis patients.
  6. Intraocular tension relieving: a significant reduction in ocular pressure was seen when administering CBG. The effects of fluid drainage from the eyes are very promising for treating glaucoma.
  7. Neuroprotective effect: CBG acts extremely active as a neuroprotectant, improving motor deficits and preserving striatal neurons. Great potential for preventing Huntington’s disease.

The stem cell of cannabinoids, CBG, has just begun to integrate into the scientific community. They believe CBG benefits may help to treat many ailments, from cancer to anxiety. While more cannabigerol research is welcome, the substance is non-toxic and non-addictive, even in therapeutic doses, so we welcome you to try it yourself!

CBG compared to CBDa, CBD and CBN

The mentioned substances are different cannabinoids that are either derived from the plant or are the result of the transformation of other substances. As we mentioned before, CBG is derived from the Cannabis Sativa plant and is often referred to as the mother of all cannabinoids. But how is it different from other derivatives?

CBDA (cannabidiolic acid) is one of many compounds produced by cannabis and hemp. The molecules are usually found in the plant in their original form which is an acid. It is from this form that the other substances are made when the plant is exposed to heat. CBDA, for example, transforms into CBD. We could also say it is its raw form. It is a bit more difficult to get CBG however, because it is naturally present in smaller quantities. To get larger amounts, breeders need to resort to genetics and cross-breeding.

CBD is the most known and most widely studied cannabinoid. Compared to CBN, it is present in much larger quantities and thus more widely available. This is also their biggest difference. They are both non-intoxicating and possess similar therapeutic effect, binding to the same receptors in the brain.

CBN, also known as cannabinolthe is different in that it is derived from THC and does not come naturally from the plant. We could say it is a degraded version of it and has little to no psychoactive properties. The research around it is very limited but it does suggest that the compound stimulates appetite and reduces nausea, making it a promising help for treating anorexia. It is also said to have anti-bacterial, anti-inflammatory and analgesic properties. This said, we can see that its uses are very different to those of CBG.

Using and Manufacturing CBG Products

Consuming CBG

If using CBD products is already your domain, like CBD oil, trying CBG is not going to be much different. There are already a lot of CBG products to choose from. We would suggest starting with CBG drops, as it still proves to be the best method of delivery. It contains just two ingredients, the CBG oil, and the carrier oil. CBG drops also provide accurate dose gauging and are available in many different potencies, great for experimenting.

There is also a great rise in the popularity of CBG flowers. CBG Inflorescences contain very low levels of THC (<0.2%) naturally. So the CBG buds offer a great 100% legal alternative to CBD flowers! Vaporising CBG flowers is also an advantageous route of administration since CBG has an extremely low boiling point of 58°C. 

CBG is not as soluble in supercritical CO2 as CBD. But with the right parameters, our CBG extraction is flawless!

CBG manufacturing

At Essentia Pura, the CO2 extraction experts, we have already started CBG production. Although we don’t keep CBG products in regular offers, we are open to prepare any kind of CBG formulation according to your needs:

  • full spectrum CBG Oil
  • isolate infused CBG Oil
  • CBD : CBG full-spectrum oil in various ratios
  • CBD : CBG isolate oils in various ratios
  • CBG for pets
  • Skincare with CBG
  • CBG raw ingredients
  • And many more…

The Cannabigerol compound proves to be the next big thing in the cannabis industry. And to stay ahead of the market demands, we will add CBG products to our regular offer!

To give CBG products a try, head over to our website and complete the contact form. If you would like any further information on the topic, do not hesitate to reach us at info@essentiapura.com

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11 minute read

Top 5 CBD Dropshipping Suppliers in Europe [2023 update]

Updated January 15, 2024
Written by
Avatar photo
Simon Šfiligoj
CBD Manufacturing
The information provided in our articles has undergone a thorough research process by a team of writers, editors, legal advisors, and medical experts to guarantee accuracy. Only reputable sources have been cited.
Furthermore, to ensure the most recent and relevant data, the content is consistently evaluated against current scientific literature and expert recommendations.

What do CBD products and dropshipping have in common? To start, they are both fairly new to the average consumer in Europe. But more importantly, they gained their popularity with the rise of online shopping. With CBD oil products rapidly rising in prominence and becoming a multi billion dollar market in the world, with a great outlook, a lot of people are trying to find their place in this upwards trend. We at Essentia Pura will try our best to explain the possibility that CBD dropshipping offers in this exciting industry.

What is CBD dropshipping

As with any topic, we believe it is best to start with the basics. So, what is CBD and what is dropshipping and is there a good enough market for CBD dropshipping?

CBD (cannabidiol) is a non-psychoactive substance derived from the cannabis plant with great health potential. CBD started trending in recent years as a legal cannabis-derived ingredient in various products. Thanks to the internet, CBD hype grew rapidly, and thanks to e-commerce it was made readily available to everyone. At the same time the rapidly growing e-commerce industry also rediscovered dropshipping. 

Dropshipping is a retail business model where the retailer offers products to consumers, but the product moves directly from the wholesaler or manufacturer to the final consumer, without being handled or stored by the retailer, thus significantly reducing your operating costs.

This service was already known in the previous century, mostly via telephone and mail orders. In the era of online shopping, dropshipping has resurged. With companies such as e-bay, Amazon, AliExpress, and Shopify getting involved, dropshipping has exploded.

Having someone else do the shipping and packaging, without keeping stock, saves a lot of time and energy!

Dropshipping, the e-commerce model that is redefining the industry, and CBD, the ultimate wellness product. Don’t they seem like the perfect combination? If you are interested in finding out how dropshipping and CBD oil products fit together and if dropshipping is the right strategy for your business, read below!

Selling CBD Products From Home

The main advantage of dropshipping is its simplicity. From the comfort of your home, you can run your business without most of the hassle. 

How to start a CBD dropshipping business

If you are interested in trying out CBD dropshipping there are some things to consider.

The first step is carefully researching the market you want to enter, this means researching if there is proper demand for CBD oil and who your main competitors are. It is always recommended to check the legal status of CBD oil in your preferred market. The legal status is important as it can effect how you can market your CBD dropshipping business.

The next step is choosing the product, in best case scenario, this should be a product you identified as interesting during your market research. Now you have to choose the supplier who offers the product you are interested in. The only thing that is left is finding consumers to purchase the product from you and get it shipped from your supplier to your consumer. Without any costs involved in manufacturing, storing, and logistics, you become the armchair middleman and collect your markup.

Market-Ready CBD products

Launch your CBD brand hassle-free by leveraging our white label CBD products. Shift your focus to strategic marketing.

White Label solution

All of this seems pretty easy, and we will help you even further with the list of trusted European dropshippers. The only thing you have to do is to find buyers and generate traffic. 

Building your brand starts with choosing a brand name, a logo, and establishing a website. Increasing your online presence can be done with blogs, posts on social media like Facebook, and through influencers from Youtube and Instagram. You can also rank your website on search engines and pay for Google Ads to increase your visibility in the market. 

Increasing your online presence with digital marketing is an art of its own. And if that is your thing, dropshipping is the way! You can fully focus on your brand, from the design to customer support, while your dropshipping partner will take care of the rest.

If venturing into CBD business, dropshipping is the tool of the trade!

Pros of CBD dropshipping 

So far dropshipping looks like the ideal business model to get involved in CBD sales. Let’s explore some of the upsides and benefits it offers.

Low setting up costs 

The website and brand design are the biggest costs involved before you are fully operational. If you have the skills required to do it yourself, or if you perhaps already have an up and running online store, you are almost covered! As explained above, you will not bear any packaging or storage costs, which can be significant as they include labor costs for packaging and rental costs for storage.

No stock 

As you are shipping everything from your CBD dropshipping company, you do not have to stock your inventory yourself, again significantly reducing costs and freeing your time to pursue business development.

No Inventory 

No inventory means you do not have to worry about CBD products being unsold or expiring. In addition to that you also do not have to deal with the transport logistics and have far greater flexibility to transition to different suppliers if you so choose.

Scalability 

If you see that your sales are increasing and you project the increase to continue, you do not have to expand your personnel, production or storage, but can only pour the extra profits into further marketing activities to expand your reach and grow your business.

Custom Formulations Private Label Solution

With a smooth product development process we can create private-label CBD products specific to your needs. Feel free to give us a call and share your idea with us without hesitation.

See private label

Cons of CBD dropshipping 

As any business activity, CBD dropshipping is not always smooth sailing. These are some of the disadvantages you might encounter along the way:

Long delivery times

As you are not keeping your own inventory, it can take longer to dispatch the order after it was paid, which can lead to customer dissatisfaction. Always carefully consider the terms and conditions of your suppliers, as you grow you might even have some power to influence their delivery times.

Quality control 

The orders are not fulfilled by you so you cannot know whether the shipped product was defective. This is why you should always carefully research your suppliers and only deal with properly certified companies that can back up their claims with lab confirmed quality control certificates.

No bulk discounts 

Selling large quantities does not result in better prices as with purchasing the same amounts wholesale, however you must be aware that your final operating costs are still lower, so this might even work out in your favor.

Refunds are costly 

If the customers are not satisfied with the delivered CBD products and these are returned you may have to cover the costs involved.

Most of the cons above vary depending on the terms you agreed with your CBD drop shipping partner, which you may not be able to influence at the start. 

Every CBD dropshipping company has its own dropshipping system, which one is the most suitable for your CBD business?

If you have the skills and resources, you can do the brand and package design yourself. Otherwise, hiring a professional might be feasible!

Who in Europe can help you with dropshipping CBD products

Choose wisely when selecting your CBD dropshipper. The price of CBD products is important, but it is not the only thing that counts. Do not overlook the quality of the CBD products, how they are produced and what packaging is used. Be especially cautious on the dropshipping terms and conditions so you do not get caught up in legal trouble, if you want to reorient your business!

1 Cibdol

The Dutch CBD manufacturer Cibdol is one of the leaders in the European market. They use hemp of the highest quality as they take care of their product from the seeds onwards. This is why they regularly test the soil the hemp grows in and only work with trusted and proven suppliers. FUrthermore they produce their CBD products in state of the art Swiss laboratories, with a special process aimed at eliminating impurities in their products and thus setting a high bar in quality control. The quality of the product is ensured by a independent third party lab.

Their sales and customer service team is always at your disposal to support you and help you to optimize and grow your business.

If you are ready to start your CBD adventure, try and contact them to set the terms of your cooperation!

2 Global Cannabinoids

This US-based CBD company from Nevada is one of the biggest global distributors of CBD products. Partnered with US hemp farmers and processors, their supply chain reaches wholesalers and retailers to all parts of the world. 

Their CBD range will satisfy most CBD consumer’s needs, but what stands out is their unique dropshipping program. In addition to standard dropshipping order fulfillment, they will, in a matter of weeks, set you up with everything you need to start your CBD business! From website design to logo and label design and label print. 

They offer 1 on 1 consulting on branding and even take care of credit card payment processing. 

Check out their website https://www.cbdstartup.io/ for more information about their plans and pricings. With the basic subscription, your CBD store can be up and running in just a week!

The subscription plans are not cheap, but considering the value, it is a viable option for those without an existing CBD business.

3 The Real CBD

The Real CBD is a family-owned business from Spain. The Spanish hemp, CO2 extraction, and their passion for CBD are making the customers happy since 2017. With +4 years of experience in the (wholesale) hemp industry, they strive to provide you support, insights, and tips to get your own CBD platform off the ground.

Their dropshipping program is simple, free and available for Europe, the UK, Canada, Mexico and The United States. If you have a webshop ready, contact the sales team at info@therealcbd.com, to receive their dropshipping package.

The Real CBD can supply:

  • Organic full-spectrum CBD oils
  • CBD products for pets and animals
  • Water-soluble CBD Powder
  • CBD topicals/beauty products
  • CBP Vape products
  • CBD supplements
  • CBD candy

Your profit margin is based on the volume of sales, and you can cancel anytime at no charge!

4 Reakiro

The Polish CBD Powerhouse is one of the biggest players in the region. Reakiro, a HACCP/GMP certified manufacturer and supplier of full-spectrum CBD oils, creams and capsules is offering their dropshipping program at no startup costs!

This dropshipping program a classic one, but Reakiro’s CBD product range and prices are not to pass. Fill the form here to apply, and get access to 50% discounts, free shipping and no MOQs, and to never worry again about:

  • Managing or paying for a warehouse
  • Packing and shipping your orders
  • Continually ordering products and managing stock level
  • Paying sales tax, import duties, customs fees, etc.
Simple, yet effective!

5 JM-Wholesale

If you are from the UK and looking for a drop shipping partner, JM-Wholesale might be just the one for you! Founded in 2017, JM-Wholesale is now UK’s largest wholesaler within the vaping, CBD, and smoking categories. With them, you will have access to an impressive diversity of CBD products by leading CBD brands, which can be dropshipped to 180 countries around the world.

JM’s advanced dropshipping program is a fully integrated and fully automated dropshipping solution. You can now upload CBD products, sync inventory & route orders with their drop shipping system to virtually any online store, marketplace, or e-commerce platform. (Woocommerce, Shopify, Weebly,.)

They provide world-class fulfilment of any scale, 24/7 support, and they even help you create a website for your new business. 

All you need to do is focus on marketing and growing your business!

The Premium package obviously costs more. but considering the fees are smaller, the returns are way higher if the volume of sales is there.

Working With CBD Dropshippers

Dropshipping CBD has never been easier, as there are plenty of CBD suppliers to choose from! The choice might not be an easy one. 

If you are new to the e-commerce world, we suggest the following CBD drop shipping tips :

  • Start with a free program or the least expensive subscription plan.
  • Choose a well established CBD brand before starting your private label.
  • Begin with one product to get the feel of things and diversify later.
  • Always order a sample to see its quality, from content to packaging.
  • Make sure the parcel will have only your details and not from your CBD drop shipping partner. You do not want to lose customers this way!
  • Focus on the marketing aspects on what will drive the business and what will increase traffic.
  • Try to get the most out of the free consulting your CBD dropshipping partner offers. Knowledge is gold! 

If you are already operating in the online sales, but new to the CBD world, make sure your CBD dropshipper should:

  • Provide you with full and correct company information, do not fall for frauds and scams. Check the authenticity through reviews and details and publicly available company reports.
  • Be transparent and responsive in communication.
  • Provide you with quality-controlled products backed up by lab reports and certificates.
  • Ensure product traceability with batch id and lot numbers.
  • Set terms on delivery times, order insurance and product returns.

Is CBD dropshipping profitable

We believe that with the right CBD dropshipping company, your CBD sales have tremendous potential to be profitable, as your operating costs are low and your risk is small. You should prepare a sound business plan and maintain a good grip on your other expenses while maintaining focus on customer acquisition. It is a well-known fact that loyal customers will be your biggest asset and your path to scaling your business! Nevertheless, you should always keep in mind that a dropshipping business is only successful if itis backed by a professional company providing you with reliable supply and quality-assured products. 

Essentia Pura Is One Of The leading CBD manufacturers and suppliers in Europe. We do not offer Dropshipping, as we do not have a B2C brand and we specialize in White Label and Private Label CBD Products for your CBD business. So in case you are looking for what we believe are the Highest-Quality CBD Products At Great Wholesale Prices labelled under your brand, Do Not Hesitate To Contact Us! Use The Contact Form Here Or Send Us An Inquiry At Info@Essentiapura.Com

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